Panghal Archna, Flora S J S
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research-SAS Nagar, Mohali, 160102, India.
Era College of Pharmaceutical Sciences, Era Lucknow Medical University, Sarfarajgang, Lucknow, 226002, India.
Discov Nano. 2024 Oct 28;19(1):171. doi: 10.1186/s11671-024-04135-0.
Multiple sclerosis (MS) is a neuroimmunological disorder which causes axonal damage, demyelination and paralysis. Although numerous therapeutics have been developed for the effective treatment of MS and a few have been approved in recent decades, complete remission and treatment of MS remain a matter of concern. Nanotechnology is a potential approach for manipulating the properties of materials at the molecular level to attain desired properties. This approach is effective in the treatment of several CNS disorders by enhancing drug delivery, bioavailability and efficacy. We have briefly discussed the neuroimmunological disorders with a particular emphasis on MS. We also explored nanoengineered drug delivery systems, describing several nano-formulations for the treatment of MS, challenges and future of nanotechnology.
多发性硬化症（MS）是一种神经免疫性疾病，可导致轴突损伤、脱髓鞘和瘫痪。尽管近几十年来已经开发出许多用于有效治疗MS的疗法，并且有几种已获批准，但MS的完全缓解和治疗仍然是一个令人关注的问题。纳米技术是一种在分子水平上操纵材料特性以获得所需特性的潜在方法。这种方法通过提高药物递送、生物利用度和疗效，在治疗几种中枢神经系统疾病方面是有效的。我们简要讨论了神经免疫性疾病，特别强调了MS。我们还探讨了纳米工程药物递送系统，描述了几种用于治疗MS的纳米制剂、纳米技术的挑战和未来。
