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壳聚糖的一般特性、生物医学和牙科应用及其在颞下颌关节紊乱症治疗中的用途：一项叙述性综述

General Characteristics, Biomedical and Dental Application, and Usage of Chitosan in the Treatment of Temporomandibular Joint Disorders: A Narrative Review.

作者信息

Derwich Marcin, Lassmann Lukasz, Machut Katarzyna, Zoltowska Agata, Pawlowska Elzbieta

机构信息

ORTODENT, Specialist Orthodontic Private Practice in Grudziadz, 86-300 Grudziadz, Poland.

Dental Sense, Dental Private Practice in Gdansk, 80-283 Gdansk, Poland.

出版信息

Pharmaceutics. 2022 Jan 27;14(2):305. doi: 10.3390/pharmaceutics14020305.

DOI:10.3390/pharmaceutics14020305
PMID:35214037
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8880239/
Abstract

The aim of this narrative review was to present research investigating chitosan, including its general characteristics, properties, and medical and dental applications, and finally to present the current state of knowledge regarding the efficacy of chitosan in the treatment of temporomandibular disorders (TMDs) based on the literature. The PICO approach was used for the literature search strategy. The PubMed database was analyzed with the following keywords: ("chitosan"[MeSH Terms] OR "chitosan"[All Fields] OR "chitosans"[All Fields] OR "chitosan s"[All Fields] OR "chitosane"[All Fields]) AND ("temporomandibular joint"[MeSH Terms] OR ("tem-poromandibular"[All Fields] AND "joint"[All Fields]) OR "temporomandibular joint"[All Fields] OR ("temporomandibular"[All Fields] AND "joints"[All Fields]) OR "temporo-mandibular joints"[All Fields]). After screening 8 results, 5 studies were included in this review. Chitosan presents many biological properties and therefore it can be widely used in several branches of medicine and dentistry. Chitosan promotes wound healing, helps to control bleeding, and is used in wound dressings, such as sutures and artificial skin. Apart from its antibacterial property, chitosan has many other properties, such as antifungal, mucoadhesive, anti-inflammatory, analgesic, antioxidant, antihyperglycemic, and antitumoral properties. Further clinical studies assessing the efficacy of chitosan in the treatment of TMD are required. According to only one clinical study, chitosan was effective in the treatment of TMD; however, better clinical results were obtained with platelet-rich plasma.

摘要

本叙述性综述的目的是介绍有关壳聚糖的研究，包括其一般特性、性质以及医学和牙科应用，最后根据文献阐述壳聚糖治疗颞下颌关节紊乱病（TMD）疗效的当前知识状态。采用PICO方法制定文献检索策略。使用以下关键词分析PubMed数据库：（“壳聚糖”[医学主题词]或“壳聚糖”[所有字段]或“壳聚糖类”[所有字段]或“壳聚糖s”[所有字段]或“壳聚糖烷”[所有字段]）与（“颞下颌关节”[医学主题词]或（“颞下颌”[所有字段]且“关节”[所有字段]）或“颞下颌关节”[所有字段]或（“颞下颌”[所有字段]且“关节”[所有字段]的复数形式）或“颞下颌关节”[所有字段的复数形式]）。在筛选了8篇结果后，本综述纳入了5项研究。壳聚糖具有多种生物学特性，因此可广泛应用于医学和牙科的多个领域。壳聚糖可促进伤口愈合、帮助控制出血，并用于伤口敷料，如缝线和人工皮肤。除了抗菌特性外，壳聚糖还具有许多其他特性，如抗真菌、粘膜粘附、抗炎、止痛、抗氧化、抗高血糖和抗肿瘤特性。需要进一步开展临床研究以评估壳聚糖治疗TMD的疗效。根据仅有的一项临床研究，壳聚糖治疗TMD有效；然而，富含血小板血浆的治疗效果更佳。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a89/8880239/97b8a3b2d084/pharmaceutics-14-00305-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a89/8880239/d9ad7a55f293/pharmaceutics-14-00305-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a89/8880239/7c258c693c72/pharmaceutics-14-00305-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a89/8880239/5bb2a5645674/pharmaceutics-14-00305-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a89/8880239/ad897edf0959/pharmaceutics-14-00305-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a89/8880239/46caa18c8d5c/pharmaceutics-14-00305-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a89/8880239/36f4fe126bcd/pharmaceutics-14-00305-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a89/8880239/97b8a3b2d084/pharmaceutics-14-00305-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a89/8880239/d9ad7a55f293/pharmaceutics-14-00305-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a89/8880239/7c258c693c72/pharmaceutics-14-00305-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a89/8880239/5bb2a5645674/pharmaceutics-14-00305-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a89/8880239/ad897edf0959/pharmaceutics-14-00305-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a89/8880239/46caa18c8d5c/pharmaceutics-14-00305-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a89/8880239/36f4fe126bcd/pharmaceutics-14-00305-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a89/8880239/97b8a3b2d084/pharmaceutics-14-00305-g007.jpg

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