Luo Xunrong, Miller Stephen D, Shea Lonnie D
Department of Medicine, Division of Nephrology and Hypertension.
Comprehensive Cancer Center, and.
Annu Rev Biomed Eng. 2016 Jul 11;18:181-205. doi: 10.1146/annurev-bioeng-110315-020137. Epub 2016 Feb 24.
The undesired destruction of healthy cells, either endogenous or transplanted, by the immune system results in the loss of tissue function or limits strategies to restore tissue function. Current therapies typically involve nonspecific immunosuppression that may prevent the appropriate response to an antigen, thereby decreasing humoral immunity and increasing the risks of patient susceptibility to opportunistic infections, viral reactivation, and neoplasia. The induction of antigen-specific immunological tolerance to block undesired immune responses to self- or allogeneic antigens, while maintaining the integrity of the remaining immune system, has the potential to transform the current treatment of autoimmune disease and serve as a key enabling technology for therapies based on cell transplantation.
免疫系统对健康细胞（无论是内源性的还是移植的）的意外破坏会导致组织功能丧失，或限制恢复组织功能的策略。目前的治疗方法通常涉及非特异性免疫抑制，这可能会阻止对抗原的适当反应，从而降低体液免疫，并增加患者易患机会性感染、病毒再激活和肿瘤形成的风险。诱导对抗原的特异性免疫耐受以阻断对自身或同种异体抗原的不良免疫反应，同时保持其余免疫系统的完整性，有可能改变目前自身免疫性疾病的治疗方法，并成为基于细胞移植的治疗的关键 enabling 技术。
