Corresponding Author: Polly A. Newcomb, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4-B402, Seattle, WA 98109.
Cancer Epidemiol Biomarkers Prev. 2012 Nov;21(11):1966-73. doi: 10.1158/1055-9965.EPI-12-0672. Epub 2012 Aug 29.
Randomized trial evidence shows that nonsteroidal anti-inflammatory drug (NSAID) use, particularly long-term use, reduces the incidence of colorectal neoplasia. Recent data also suggests an inverse association between NSAID use and death due to colorectal cancer (CRC).
We examined the association between NSAID use and CRC mortality among 160,143 postmenopausal women enrolled in the Women's Health Initiative. Women provided details on medication use at baseline and three years after enrollment. Reported CRC cases were locally confirmed and centrally adjudicated; cause of death was determined according to centralized medical record and death certificate review. Cox regression was used to investigate the association between NSAID use and CRC mortality.
Overall, NSAID use at baseline was not associated with CRC mortality [HR: 0.93; 95% confidence interval (CI) 0.76, 1.14]. However, women who reported NSAID use at both baseline and year 3 experienced reductions in CRC mortality (HR: 0.72; 95% CI 0.54, 0.95) compared with nonusers.
Results suggest that NSAID use is associated with lower CRC mortality among postmenopausal women who use these medications more consistently over time. impact: Our results support prolonged NSAID use in postmenopausal women for the prevention of poor CRC outcomes.
随机试验证据表明，非甾体抗炎药（NSAID）的使用，特别是长期使用，可降低结直肠肿瘤的发生率。最近的数据还表明，NSAID 的使用与结直肠癌（CRC）死亡之间呈负相关。
我们研究了 160143 名参加妇女健康倡议的绝经后妇女中 NSAID 使用与 CRC 死亡率之间的关系。女性在基线和入组后 3 年提供了药物使用的详细信息。报告的 CRC 病例经局部确认和中心裁决；根据集中的病历和死亡证明审查确定死亡原因。Cox 回归用于研究 NSAID 使用与 CRC 死亡率之间的关系。
总体而言，基线时 NSAID 的使用与 CRC 死亡率无关[HR：0.93；95%置信区间（CI）0.76，1.14]。然而，与未使用者相比，同时在基线和第 3 年报告 NSAID 使用的女性 CRC 死亡率降低（HR：0.72；95%CI 0.54，0.95）。
结果表明，在长期持续使用这些药物的绝经后妇女中，NSAID 的使用与 CRC 死亡率降低相关。影响：我们的结果支持绝经后妇女延长 NSAID 使用时间，以预防 CRC 不良结局。
