社区视角：结合血清学、遗传学和炎症标志物用于炎症性肠病的诊断及克罗恩病与溃疡性结肠炎的鉴别诊断
Community Perspectives: Combining Serology, Genetics, and Inflammation Markers for the Diagnosis of IBD and Differentiation Between CD and UC.
作者信息
Wolf Douglas C, Abraham Bincy P, Afzali Anita, Allegretti Paul D, Arai Ronen
机构信息
Atlanta Gastroenterology Associates Atlanta, Georgia.
出版信息
Gastroenterol Hepatol (N Y). 2012 Jun;8(6 Suppl 2):1-16.
Abstract
Diagnosis of inflammatory bowel disease (IBD) is complicated and is based on a combination of patient history and physical examination in association with laboratory, endoscopic, histologic, and radiographic investigations. Determination of the correct diagnosis is important for its implications in selecting treatment and in the timing and type of surgery that may be required. Information from testing incorporating serologic, genetic, and inflammatory markers can help to clarify the clinical picture. Measurement of biomarkers not only helps to differentiate a diagnosis of IBD versus non-IBD, it can also help to distinguish between ulcerative colitis and Crohn's disease in difficult cases. In this monograph, 5 cases illustrate how specialized testing can provide important information that can aid in diagnosis.
摘要
炎症性肠病（IBD）的诊断较为复杂，它基于患者病史、体格检查，并结合实验室检查、内镜检查、组织学检查和影像学检查。正确诊断对于选择治疗方法以及确定可能需要的手术时机和类型具有重要意义。包含血清学、遗传学和炎症标志物的检测信息有助于明确临床情况。生物标志物的检测不仅有助于鉴别IBD与非IBD，在疑难病例中还能帮助区分溃疡性结肠炎和克罗恩病。在本专著中，5个病例说明了专项检测如何能提供有助于诊断的重要信息。
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