Calipari Erin S, España Rodrigo A
Department of Physiology and Pharmacology, Wake Forest School of Medicine Winston Salem, NC, USA.
Front Behav Neurosci. 2012 Aug 21;6:54. doi: 10.3389/fnbeh.2012.00054. eCollection 2012.
The hypocretins/orexins are comprised of two neuroexcitatory peptides that are synthesized exclusively within a circumscribed region of the lateral hypothalamus. These peptides project widely throughout the brain and interact with a variety of regions involved in the regulation of arousal-related processes including those associated with motivated behavior. The current review focuses on emerging evidence indicating that the hypocretins influence reward and reinforcement processing via actions on the mesolimbic dopamine system. We discuss contemporary perspectives of hypocretin regulation of mesolimbic dopamine signaling in both drug free and drug states, as well as hypocretin regulation of behavioral responses to drugs of abuse, particularly as it relates to cocaine.
下丘脑泌素/食欲素由两种神经兴奋性肽组成，它们仅在下丘脑外侧的一个限定区域内合成。这些肽广泛投射至整个大脑，并与参与调节觉醒相关过程的多种区域相互作用，包括那些与动机行为相关的区域。本综述聚焦于新出现的证据，这些证据表明下丘脑泌素通过作用于中脑边缘多巴胺系统来影响奖赏和强化过程。我们讨论了在无药物和有药物状态下，下丘脑泌素对中脑边缘多巴胺信号调节的当代观点，以及下丘脑泌素对滥用药物行为反应的调节，特别是与可卡因相关的调节。
