J Thorac Dis. 2012 Aug;4(4):377-83. doi: 10.3978/j.issn.2072-1439.2012.08.02.
To investigate the relationship between respiratory viral load and lung lesion severity of patients with pandemic H1N1 2009 influenza A pneumonia.
Cross-sectional observation study.
24 consecutive H1N1 influenza patients with viral pneumonia (13 males, 11 females, mean age: 17.5 years) during their presentation to hospital were retrospectively analysed. Viral load were first measured on average 5.2 days after the onset of symptoms. The initial CT and viral load measurement was carried on the same day in 13 patients. The rest were carried out with a mean interval time of 1.5 days. All patients had viral load follow-up till turned negative. Thirteen patients had radiological follow-up.
There was no significant correlation between the initial lung lesion severity and viral load (P=0.4). Both viral load and lung lesion severity decreased over time, being highest value at initial presentation. The patients had higher initial viral load or higher initial lung lesion severity tended to be slower in resolving. The lung lesion decreased at a slower rate than viral load.
While there was no correlation between the initial viral load and lung lesion severity, these two indices provide valuable information for epidemiological control.
探讨 2009 年甲型 H1N1 流感病毒肺炎患者呼吸道病毒载量与肺部病变严重程度的关系。
横断面观察研究。
回顾性分析了 24 例连续的甲型 H1N1 流感病毒性肺炎患者（男 13 例，女 11 例，平均年龄：17.5 岁）。病毒载量在症状出现后平均 5.2 天进行首次测量。13 例患者在同一天进行了初始 CT 和病毒载量测量，其余患者的间隔时间平均为 1.5 天。所有患者的病毒载量均持续检测至转阴。13 例患者进行了影像学随访。
初始肺部病变严重程度与病毒载量之间无显著相关性（P=0.4）。病毒载量和肺部病变严重程度随时间推移而下降，在初始表现时达到最高值。初始病毒载量较高或初始肺部病变严重程度较高的患者，其恢复速度较慢。肺部病变的下降速度比病毒载量慢。
虽然初始病毒载量与肺部病变严重程度之间无相关性，但这两个指标为流行病学控制提供了有价值的信息。
