Pharmaceutical and Biomedical Sciences Department (FARMABIOMED); University of Salerno; Fisciano, Italy.
Oncoimmunology. 2012 Aug 1;1(5):726-734. doi: 10.4161/onci.20171.
In the last decade several studies provided evidence that plasmacytoid dendritic cells (pDCs) infiltrate human neoplasms with poor prognosis. However, the role of tumor-associated pDCs remains controversial. Various studies indicate that pDCs play an immuno-suppressive role and facilitate tumor progression in both animal models and humans. In contrast, others found that the presence of activated tumor-associated pDCs results in tumor regression in mice. Given these findings, understanding pDC function in tumor biology is an important necessity and may pave the way for novel therapeutic strategies to fight malignancies.
在过去的十年中，有几项研究提供了证据表明浆细胞样树突状细胞（pDCs）浸润到预后不良的人类肿瘤中。然而，肿瘤相关 pDCs 的作用仍然存在争议。各种研究表明，pDCs 在动物模型和人类中均发挥免疫抑制作用并促进肿瘤进展。相比之下，其他研究发现激活的肿瘤相关 pDCs 的存在可导致小鼠肿瘤消退。鉴于这些发现，了解 pDC 在肿瘤生物学中的功能是一个重要的需求，并且可能为对抗恶性肿瘤的新治疗策略铺平道路。
