Ye Yishan, Gaugler Béatrice, Mohty Mohamad, Malard Florent
INSERM, Centre de Recherche Saint-Antoine (CRSA) Sorbonne Université Paris France.
Bone Marrow Transplantation Center The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou China.
Clin Transl Immunology. 2020 May 26;9(5):e1139. doi: 10.1002/cti2.1139. eCollection 2020 May.
Plasmacytoid dendritic cells (pDCs) are a unique subset of dendritic cells specialised in secreting high levels of type I interferons. pDCs play a crucial role in antiviral immunity and have been implicated in the initiation and development of many autoimmune and inflammatory diseases. This review summarises the latest advances in recent years in several aspects of pDC biology, with special focus on pDC heterogeneity, pDC development via the lymphoid pathway, and newly identified proteins/pathways involved in pDC trafficking, nucleic acid sensing and interferon production. Finally, we also highlight the current understanding of pDC involvement in autoimmunity and alloreactivity, and opportunities for pDC-targeting therapies in these diseases. These new insights have contributed to answers to several fundamental questions remaining in pDC biology and may pave the way to successful pDC-targeting therapy in the future.
浆细胞样树突状细胞（pDC）是树突状细胞的一个独特亚群，专门分泌高水平的I型干扰素。pDC在抗病毒免疫中起关键作用，并与许多自身免疫性和炎性疾病的发生及发展有关。本综述总结了近年来pDC生物学几个方面的最新进展，特别关注pDC的异质性、通过淋巴途径的pDC发育，以及新发现的参与pDC迁移、核酸传感和干扰素产生的蛋白质/途径。最后，我们还强调了目前对pDC参与自身免疫和同种异体反应性的理解，以及针对这些疾病的pDC靶向治疗的机会。这些新见解有助于解答pDC生物学中仍存在的几个基本问题，并可能为未来成功的pDC靶向治疗铺平道路。
