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先天免疫识别乳腺肿瘤细胞介导 CCL22 分泌有利于 Treg 在肿瘤微环境中的募集。

Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment.

机构信息

Université de Lyon; Lyon, France ; Université Lyon 1; ISPB; Lyon, France ; Team 11; CRCL INSERM U-1052/CNRS 5286; Lyon, France ; LabEx DEVweCAN; Centre Léon Bérard; Lyon, France ; Centre Léon Bérard; Lyon, France.

出版信息

Oncoimmunology. 2012 Aug 1;1(5):759-761. doi: 10.4161/onci.19680.

DOI:10.4161/onci.19680
PMID:22934274
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3429586/
Abstract

Regulatory T cells (Treg) have been reported of poor prognosis for overall survival in primary breast tumors (BT). As CCL22 plays a major role in Treg recruitment within primary BT we deciphered the mechanisms involved in the CCL22 production by breast epithelial tumor cells and propose herein the major role of their innate immune recognition in this production.

摘要

调节性 T 细胞（Treg）在原发性乳腺癌（BT）中的总生存率预后不良。由于 CCL22 在原发性 BT 中的 Treg 募集中起着重要作用，我们阐明了乳腺上皮肿瘤细胞产生 CCL22 所涉及的机制，并在此提出了它们的固有免疫识别在这种产生中的主要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d8b/3429586/8ffd0f107a71/onci-1-759-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d8b/3429586/8ffd0f107a71/onci-1-759-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d8b/3429586/8ffd0f107a71/onci-1-759-g1.jpg

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