开发新型通用免疫受体用于抗原靶向：超越无限。
Development of a novel universal immune receptor for antigen targeting: To Infinity and beyond.
机构信息
Department of Pathology and Laboratory Medicine; University of Pennsylvania; Philadelphia, PA USA.
出版信息
Oncoimmunology. 2012 Aug 1;1(5):777-779. doi: 10.4161/onci.19730.
Abstract
Chimeric antigen receptors (CARs) possess fixed specificity for a single antigen and require empirical testing in T cells. To address this, we have developed a novel, adaptable immune receptor strategy that allows for the rapid generation and testing of T cells of nearly infinite antigen specificity.
摘要
嵌合抗原受体（CARs）对单一抗原具有固定的特异性，并且需要在 T 细胞中进行实证测试。为了解决这个问题，我们开发了一种新颖的、适应性强的免疫受体策略，能够快速生成和测试几乎具有无限抗原特异性的 T 细胞。
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