Cell Death Research and Therapy Unit; Department for Cellular and Molecular Medicine; University of Leuven (KULeuven); Leuven, Belgium.
Oncoimmunology. 2012 Aug 1;1(5):786-788. doi: 10.4161/onci.19750.
Primary induction of photo-oxidative (phox)-ER stress in cancer cells evoked immunogenic apoptosis (IA) associated with pre-apoptotic emission of calreticulin and ATP, and protective antitumor immunity. This IA subroutine involved "core" functions (e.g., PERK/PI3K-based modulation of secretory trafficking) rather than "private" ones (caspase-8 and eIF2α-phosphorylation) engaged by other IA inducers.
原代诱导光氧化（phox）-内质网应激可诱发与凋亡小体提前释放钙网蛋白和 ATP 相关的免疫原性细胞凋亡（IA），并诱导保护性抗肿瘤免疫。这种 IA 子程序涉及“核心”功能（例如 PERK/PI3K 介导的分泌途径调节），而不是其他 IA 诱导剂所涉及的“私有”功能（caspase-8 和 eIF2α 磷酸化）。
