光动力疗法诱导的抗肿瘤免疫：影响因素与协同增强策略
Photodynamic Therapy-Induced Anti-Tumor Immunity: Influence Factors and Synergistic Enhancement Strategies.
作者信息
Chou Wenxin, Sun Tianzhen, Peng Nian, Wang Zixuan, Chen Defu, Qiu Haixia, Zhao Hongyou
机构信息
School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.
Department of Laser Medicine, the First Medical Center, PLA General Hospital, Beijing 100853, China.
出版信息
Pharmaceutics. 2023 Nov 11;15(11):2617. doi: 10.3390/pharmaceutics15112617.
Photodynamic therapy (PDT) is an approved therapeutic procedure that exerts cytotoxic activity towards tumor cells by activating photosensitizers (PSs) with light exposure to produce reactive oxygen species (ROS). Compared to traditional treatment strategies such as surgery, chemotherapy, and radiation therapy, PDT not only kills the primary tumors, but also effectively suppresses metastatic tumors by activating the immune response. However, the anti-tumor immune effects induced by PDT are influenced by several factors, including the localization of PSs in cells, PSs concentration, fluence rate of light, oxygen concentration, and the integrity of immune function. In this review, we systematically summarize the influence factors of anti-tumor immune effects mediated by PDT. Furthermore, an update on the combination of PDT and other immunotherapy strategies are provided. Finally, the future directions and challenges of anti-tumor immunity induced by PDT are discussed.
光动力疗法（PDT）是一种已获批准的治疗方法，通过用光照射激活光敏剂（PSs）产生活性氧（ROS），对肿瘤细胞发挥细胞毒活性。与手术、化疗和放射治疗等传统治疗策略相比，PDT不仅能杀死原发性肿瘤，还能通过激活免疫反应有效抑制转移性肿瘤。然而，PDT诱导的抗肿瘤免疫效应受多种因素影响，包括PSs在细胞内的定位、PSs浓度、光通量率、氧浓度以及免疫功能的完整性。在本综述中，我们系统总结了PDT介导的抗肿瘤免疫效应的影响因素。此外，还提供了PDT与其他免疫治疗策略联合应用的最新进展。最后，讨论了PDT诱导的抗肿瘤免疫的未来方向和挑战。
Zotero 插件