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光动力疗法诱导的抗肿瘤免疫：影响因素与协同增强策略

Photodynamic Therapy-Induced Anti-Tumor Immunity: Influence Factors and Synergistic Enhancement Strategies.

作者信息

Chou Wenxin, Sun Tianzhen, Peng Nian, Wang Zixuan, Chen Defu, Qiu Haixia, Zhao Hongyou

机构信息

School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.

Department of Laser Medicine, the First Medical Center, PLA General Hospital, Beijing 100853, China.

出版信息

Pharmaceutics. 2023 Nov 11;15(11):2617. doi: 10.3390/pharmaceutics15112617.

DOI:10.3390/pharmaceutics15112617
PMID:38004595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10675361/
Abstract

Photodynamic therapy (PDT) is an approved therapeutic procedure that exerts cytotoxic activity towards tumor cells by activating photosensitizers (PSs) with light exposure to produce reactive oxygen species (ROS). Compared to traditional treatment strategies such as surgery, chemotherapy, and radiation therapy, PDT not only kills the primary tumors, but also effectively suppresses metastatic tumors by activating the immune response. However, the anti-tumor immune effects induced by PDT are influenced by several factors, including the localization of PSs in cells, PSs concentration, fluence rate of light, oxygen concentration, and the integrity of immune function. In this review, we systematically summarize the influence factors of anti-tumor immune effects mediated by PDT. Furthermore, an update on the combination of PDT and other immunotherapy strategies are provided. Finally, the future directions and challenges of anti-tumor immunity induced by PDT are discussed.

摘要

光动力疗法（PDT）是一种已获批准的治疗方法，通过用光照射激活光敏剂（PSs）产生活性氧（ROS），对肿瘤细胞发挥细胞毒活性。与手术、化疗和放射治疗等传统治疗策略相比，PDT不仅能杀死原发性肿瘤，还能通过激活免疫反应有效抑制转移性肿瘤。然而，PDT诱导的抗肿瘤免疫效应受多种因素影响，包括PSs在细胞内的定位、PSs浓度、光通量率、氧浓度以及免疫功能的完整性。在本综述中，我们系统总结了PDT介导的抗肿瘤免疫效应的影响因素。此外，还提供了PDT与其他免疫治疗策略联合应用的最新进展。最后，讨论了PDT诱导的抗肿瘤免疫的未来方向和挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/b6dd39916e0d/pharmaceutics-15-02617-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/cad9461fc95e/pharmaceutics-15-02617-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/d42c7bd0cf59/pharmaceutics-15-02617-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/28ed9e08f1af/pharmaceutics-15-02617-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/cc536153ecb9/pharmaceutics-15-02617-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/690db8080b93/pharmaceutics-15-02617-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/2611f09ed013/pharmaceutics-15-02617-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/93057fa227d8/pharmaceutics-15-02617-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/a993d6b67443/pharmaceutics-15-02617-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/8596caf766aa/pharmaceutics-15-02617-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/b6dd39916e0d/pharmaceutics-15-02617-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/cad9461fc95e/pharmaceutics-15-02617-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/d42c7bd0cf59/pharmaceutics-15-02617-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/28ed9e08f1af/pharmaceutics-15-02617-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/cc536153ecb9/pharmaceutics-15-02617-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/690db8080b93/pharmaceutics-15-02617-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/2611f09ed013/pharmaceutics-15-02617-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/93057fa227d8/pharmaceutics-15-02617-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/a993d6b67443/pharmaceutics-15-02617-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/8596caf766aa/pharmaceutics-15-02617-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c629/10675361/b6dd39916e0d/pharmaceutics-15-02617-g009.jpg

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Photodynamic Therapy-Induced Anti-Tumor Immunity: Influence Factors and Synergistic Enhancement Strategies.

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引用本文的文献

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A pH-Sensitive Nanosized Covalent-Organic Polymer for Enhanced Tumor Photodynamic Immunotherapy by Hypoxia Relief and STAT3 Inhibition.

Adv Sci (Weinh). 2025-8

[2]
Photodynamic Therapy in Cancer: Insights into Cellular and Molecular Pathways.

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[3]
Antitumor immunostimulatory effect via cell-killing action of a novel extracorporeal blood circulating photodynamic therapy system using 5-aminolevulinic acid.

Sci Rep. 2025-1-7

[4]
Photodynamic Therapy Using IR-783 Liposomes for Advanced Tongue and Breast Cancers in Humans.

J Funct Biomater. 2024-12-2

[5]
Functionalized and Theranostic Lipidic and Tocosomal Drug Delivery Systems: Potentials and Limitations in Cancer Photodynamic Therapy.

Adv Pharm Bull. 2024-10

[6]
Nanomaterials: leading immunogenic cell death-based cancer therapies.

Front Immunol. 2024

[7]
Photoimmunotherapy for cancer treatment based on organic small molecules: Recent strategies and future directions.

Transl Oncol. 2024-11

[8]
Cyanine dyes in the mitochondria-targeting photodynamic and photothermal therapy.

Commun Chem. 2024-8-13

[9]
The Latest Look at PDT and Immune Checkpoints.

Curr Issues Mol Biol. 2024-7-8

[10]
Advances in Nanodynamic Therapy for Cancer Treatment.

Nanomaterials (Basel). 2024-4-8

本文引用的文献

[1]
Nanocarriers for photodynamic-gene therapy.

Photodiagnosis Photodyn Ther. 2023-9

[2]
Multi-shell structured upconversion nanocarriers that combine IDO inhibitor-induced immunotherapy with NIR-triggered photodynamic therapy for deep tumors.

Biomater Sci. 2023-6-27

[3]
Recent advances in type I organic photosensitizers for efficient photodynamic therapy for overcoming tumor hypoxia.

J Mater Chem B. 2023-5-31

[4]
Self-delivery photodynamic-hypoxia alleviating nanomedicine synergizes with anti-PD-L1 for cancer immunotherapy.

Int J Pharm. 2023-5-25

[5]
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Nanoscale metal-organic framework delivers rapamycin to induce tissue immunogenic cell death and potentiates cancer immunotherapy.

Nanomedicine. 2023-6

[7]
Type I Photosensitizer Targeting G-Quadruplex RNA Elicits Augmented Immunity for Cancer Ablation.

Angew Chem Int Ed Engl. 2023-4-17

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Hot-band absorption assisted single-photon frequency upconversion luminescent nanophotosensitizer for 808 nm light triggered photodynamic immunotherapy of cancer.

Biomater Sci. 2023-3-14

[9]
Anti-tumor immunity enhancement by photodynamic therapy with talaporfin sodium and anti-programmed death 1 antibody.

Mol Ther Oncolytics. 2023-1-2

[10]
Chlorin e6-induced photodynamic effect facilitates immunogenic cell death of lung cancer as a result of oxidative endoplasmic reticulum stress and DNA damage.

Int Immunopharmacol. 2023-2

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