Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, 21 Sassoon Road, Hong Kong, China.
Curr Stem Cell Res Ther. 2012 Nov;7(6):389-99. doi: 10.2174/157488812804484611.
The past decade has witnessed numerous publications on mesenchymal stem cells (MSC), which have great potential in regenerative medicine. MSC from various types of origins exhibit different characteristics, which may relate to the maintenance role of MSC in that specific source. Reports have emerged that among the most widely investigated sources, umbilical cord (UC) or umbilical cord blood (UCB) derived MSC throw advantages over bone marrow (BM) derived MSC due to their close to fetal origin. Here the methodologies used to separate MSC from UC or UCB, and the intrinsic properties, including proliferation capacity, multipotency, cytokine profile, cell surface protein expression and gene expression, between UC, UCB and BM derived MSC, are discussed in details, though may not in a full picture, for the first time.
过去十年见证了大量关于间充质干细胞（MSC）的出版物，这些细胞在再生医学中有很大的潜力。来自不同来源的 MSC 表现出不同的特性，这可能与 MSC 在特定来源中的维持作用有关。有报道称，在最广泛研究的来源中，脐带（UC）或脐带血（UCB）来源的 MSC 由于其接近胎儿起源，优于骨髓（BM）来源的 MSC。在这里，首次详细讨论了从 UC 或 UCB 分离 MSC 的方法，以及 UC、UCB 和 BM 来源的 MSC 之间的内在特性，包括增殖能力、多能性、细胞因子谱、细胞表面蛋白表达和基因表达。
