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[作为异源生物代谢酶活性调节剂的膳食蛋白质。环氧水解酶]

[Dietary protein as a modulator of the activity of enzymes metabolizing xenobiotics. Epoxide hydrolase].

作者信息

Tutel'ian V A, Kravchenko L V, Kuz'mina E E

出版信息

Vopr Pitan. 1990 Nov-Dec(6):61-4.

PMID:2293455
Abstract

Growing male rats received rations containing 5.18 and 33% of protein during 2 months. In contrast to other microsomal enzymes, epoxide hydrolase activity was maximal in the liver of the animals which received the ration with 5% of protein, and minimal--with 18% of protein. Epoxide hydrolase in the liver of rats that received the rations with 5 and 18% of protein showed equally expressed capacity for induction and activation in vivo and in vitro.

摘要

在两个月的时间里,生长中的雄性大鼠分别摄取了蛋白质含量为5%和18%的日粮。与其他微粒体酶不同,环氧水解酶的活性在摄取5%蛋白质日粮的动物肝脏中最高,而在摄取18%蛋白质日粮的动物肝脏中最低。摄取5%和18%蛋白质日粮的大鼠肝脏中的环氧水解酶在体内和体外均表现出同等程度的诱导和激活能力。

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