Departamento de Biofísica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Curr Med Chem. 2012;19(25):4359-66. doi: 10.2174/092986712802884312.
Coronary Artery Disease (CAD) and
Sleep Disordered Breathing (SDB) are both oxidative stress disorders. SDB intermittent hypoxia induces oxidative stress, and reduces NO(·) availability, causing endothelial dysfunction. Low-density lipoprotein (LDL) peroxidation is involved in atherosclerosis, and is reported in SDB. Oxidized LDL (ox-LDL) and malondialdehyde (MDA) are lipid peroxidation markers. High-density lipoprotein (HDL) presents antiatherosclerotic properties related to paraxonase-1 (PON-1) activity. PON-1 hydrolyseyses lipid peroxides as ox-LDL. This study compares the relationship of HDL and PON-1, the lipid peroxidation markers ox-LDL and MDA, and 8-OHdG DNA damage marker in the association of SDB and CAD.
29 controls and 27 cases with CAD (defined as > 30% coronary narrowing) patients were included. The apnea-hypopnea index (AHI), and several lipid and oxidative stress parameters were measured in these patients.
AHI is increased in CAD patients, and PON-1 activity and HDL levels are decreased. Regression analyseyses showed that lower PON-1 activity and higher ox-LDL levels are important CAD predictors, compared to HDL or MDA levels and present an age-dependent increase. Nitrites and nitrates, indirect NO(·) markers, are positive vs correlated with PON-1 and are negatively correlated to ox-LDL. SDB is not correlated to PON-1 activity decrease or ox-LDL increase. AHI is inversely correlated to HDL levels.
These results indicate that PON-1 and ox-LDL are important predictors of CAD, however they may not be directly related to SDB.
冠状动脉疾病（CAD）和
睡眠呼吸紊乱（SDB）都是氧化应激紊乱。SDB 间歇性缺氧会引起氧化应激，降低一氧化氮（NO(·)）的可用性，导致内皮功能障碍。低密度脂蛋白（LDL）的过氧化作用参与动脉粥样硬化，并在 SDB 中被报道。氧化型 LDL（ox-LDL）和丙二醛（MDA）是脂质过氧化的标志物。高密度脂蛋白（HDL）具有与对氧磷酶-1（PON-1）活性相关的抗动脉粥样硬化特性。PON-1 可水解脂质过氧化物如 ox-LDL。本研究比较了 SDB 和 CAD 之间的 HDL 和 PON-1、脂质过氧化标志物 ox-LDL 和 MDA 以及 8-OHdG DNA 损伤标志物的关系。
纳入 29 名对照者和 27 名 CAD 患者（定义为> 30%冠状动脉狭窄）。测量这些患者的呼吸暂停-低通气指数（AHI）和几个血脂和氧化应激参数。
CAD 患者的 AHI 增加，PON-1 活性和 HDL 水平降低。回归分析表明，与 HDL 或 MDA 水平相比，较低的 PON-1 活性和较高的 ox-LDL 水平是 CAD 的重要预测因子，并且随年龄增长而增加。亚硝酸盐和硝酸盐是间接的 NO(·)标志物，与 PON-1 呈正相关，与 ox-LDL 呈负相关。SDB 与 PON-1 活性降低或 ox-LDL 增加无关。AHI 与 HDL 水平呈负相关。
这些结果表明 PON-1 和 ox-LDL 是 CAD 的重要预测因子，但它们可能与 SDB 没有直接关系。
