Rappeport J M
Yale University School of Medicine, New Haven, Connecticut.
Yale J Biol Med. 1990 Sep-Oct;63(5):445-54.
The clinical pathologic syndrome of graft-versus-host disease (GVHD) is usually a sequela of bone marrow transplantation. This disorder occurs as a result of recognition by engrafted donor-derived lymphocytes of "foreign" recipient transplantation antigens. GVHD may also result from engraftment of lymphocytes from other sources, including (1) transfusion of lymphocytes containing blood components, (2) transplacental maternal fetal transfusion, and (3) passive transfer of lymphocytes in solid organ transplantation. The recipients are usually severely immunodeficient and thus incapable of rejecting the transfused lymphocytes. This syndrome may, however, also develop in immunologically competent patients receiving blood products from individuals with histocompatibility antigens not recognized as foreign.
移植物抗宿主病（GVHD）的临床病理综合征通常是骨髓移植的后遗症。这种疾病是由于植入的供体来源淋巴细胞识别“外来”受体移植抗原而发生的。GVHD也可能由其他来源的淋巴细胞植入引起，包括（1）含有血液成分的淋巴细胞输血，（2）经胎盘的母胎输血，以及（3）实体器官移植中淋巴细胞的被动转移。受体通常严重免疫缺陷，因此无法排斥输入的淋巴细胞。然而，这种综合征也可能在接受来自具有未被识别为外来组织相容性抗原个体的血液制品的免疫功能正常的患者中发生。
