蜕膜基质细胞作为调节 T 细胞进入母胎界面的分子。
Decidual stromal cells as regulators of T-cell access to the maternal-fetal interface.
机构信息
Reproductive Immunology Unit, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA.
出版信息
Am J Reprod Immunol. 2012 Oct;68(4):279-81. doi: 10.1111/aji.12006. Epub 2012 Aug 31.
Abstract
A recent study in the journal Science offers insights into the mechanism behind feto-maternal tolerance, as evidenced by changes in the immuno-logical environment of the uterus and decidua. They also provide a rich area of research for the understanding of the regulation of the immune system in other complicated medical conditions, including cancer and pregnancies affected by infection or autoimmunity.
摘要
最近发表在《科学》杂志上的一项研究揭示了胎母免疫耐受背后的机制，这一点可以从子宫和蜕膜免疫环境的变化中得到证明。这些发现也为研究其他复杂医学条件（包括癌症和感染或自身免疫性疾病影响的妊娠）中免疫系统的调节提供了丰富的研究领域。
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本文引用的文献
1
Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface.趋化因子基因沉默抑制了树突状基质细胞中 T 细胞向母体-胎儿界面的迁移。
Science. 2012 Jun 8;336(6086):1317-21. doi: 10.1126/science.1220030.
2
Modulation and recruitment of inducible regulatory T cells by first trimester trophoblast cells.滋养层细胞对诱导性调节性 T 细胞的调节和募集。
Am J Reprod Immunol. 2012 Jan;67(1):17-27. doi: 10.1111/j.1600-0897.2011.01056.x. Epub 2011 Aug 7.
3
Inflammation and pregnancy: the role of the immune system at the implantation site.炎症与妊娠：着床部位免疫系统的作用。
Ann N Y Acad Sci. 2011 Mar;1221(1):80-7. doi: 10.1111/j.1749-6632.2010.05938.x.
4
Placental viral infection sensitizes to endotoxin-induced pre-term labor: a double hit hypothesis.胎盘病毒感染使机体对内毒素诱导的早产敏感：双打击假说。
Am J Reprod Immunol. 2011 Feb;65(2):110-7. doi: 10.1111/j.1600-0897.2010.00908.x. Epub 2010 Aug 13.
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The immune system in pregnancy: a unique complexity.妊娠期间的免疫系统：独特的复杂性。
Am J Reprod Immunol. 2010 Jun;63(6):425-33. doi: 10.1111/j.1600-0897.2010.00836.x. Epub 2010 Mar 29.
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