Reproductive Medical Center, Renmin Hospital of Wuhan University, Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan, China.
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.
Front Immunol. 2021 Oct 21;12:758281. doi: 10.3389/fimmu.2021.758281. eCollection 2021.
The immune tolerance microenvironment is crucial for the establishment and maintenance of pregnancy at the maternal-fetal interface. The maternal-fetal interface is a complex system containing various cells, including lymphocytes, decidual stromal cells, and trophoblasts. Macrophages are the second-largest leukocytes at the maternal-fetal interface, which has been demonstrated to play essential roles in remodeling spiral arteries, maintaining maternal-fetal immune tolerance, and regulating trophoblast's biological behaviors. Many researchers, including us, have conducted a series of studies on the crosstalk between macrophages and trophoblasts at the maternal-fetal interface: on the one hand, macrophages can affect the invasion and migration of trophoblasts; on the other hand, trophoblasts can regulate macrophage polarization and influence the state of the maternal-fetal immune microenvironment. In this review, we systemically introduce the functions of macrophages and trophoblasts and the cell-cell interaction between them for the establishment and maintenance of pregnancy. Advances in this area will further accelerate the basic research and clinical translation of reproductive medicine.
免疫耐受微环境对于母体-胎儿界面妊娠的建立和维持至关重要。母体-胎儿界面是一个包含各种细胞的复杂系统，包括淋巴细胞、蜕膜基质细胞和滋养层细胞。巨噬细胞是母体-胎儿界面上第二大白细胞群，已被证明在重塑螺旋动脉、维持母体-胎儿免疫耐受和调节滋养层细胞的生物学行为方面发挥着重要作用。包括我们在内的许多研究人员已经对母体-胎儿界面上巨噬细胞和滋养层细胞之间的串扰进行了一系列研究：一方面，巨噬细胞可以影响滋养层细胞的侵袭和迁移；另一方面，滋养层细胞可以调节巨噬细胞极化，并影响母体-胎儿免疫微环境的状态。在这篇综述中，我们系统地介绍了巨噬细胞和滋养层细胞的功能以及它们之间的细胞-细胞相互作用，以建立和维持妊娠。这一领域的进展将进一步加速生殖医学的基础研究和临床转化。
