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[关于甲状腺激素状态与血管内脂质代谢的动物实验和临床研究]

[Animal experiments and clinical studies on intravascular lipid metabolism in relation to thyroid hormone status].

作者信息

Rassoul F

机构信息

Institut für Klinische Chemie und Laboratoriumsdiagnostik, Bereiches Medizin der Karl-Marx-Universität Leipzig.

出版信息

Z Gesamte Inn Med. 1990 Jul 15;45(14):414-7.

PMID:2293515
Abstract

Animal-experimental and clinical investigations concerning the intravasal lipid metabolism in disturbances of the thyroid hormones were performed. The results of these investigations show adverse effects of the thyroid hormones between man and rat with regard to the metabolism of lipoproteins rich in triglycerides. While in the clinical investigations performed an increase of the activity of the post-heparin lipase in hyperthyroidism of the type of Basedow's disease, connected with low triglyceride and VLDL levels in the serum was the result, in the animal experiment an opposite behaviour was established. Inverse relations were made evident also in hypofunction of the thyroid gland.

摘要

针对甲状腺激素紊乱时血管内脂质代谢进行了动物实验和临床研究。这些研究结果表明,在富含甘油三酯的脂蛋白代谢方面,人与大鼠之间甲状腺激素存在不良影响。在针对巴塞多氏病类型的甲状腺功能亢进症进行的临床研究中,结果是肝素后脂肪酶活性增加,同时血清中甘油三酯和极低密度脂蛋白水平降低;而在动物实验中则出现了相反的情况。甲状腺功能减退时也明显存在相反的关系。

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