University of Pennsylvania, Perelman School of Medicine, Center for Sleep and Circadian Neurobiology, MPH, 3624 Market Street, Suite 205, Philadelphia, PA 19104, USA.
Stroke. 2012 Nov;43(11):2858-64. doi: 10.1161/STROKEAHA.112.660332. Epub 2012 Aug 30.
Carotid intima-media thickness (CIMT) is a subclinical marker of cardiovascular disease. Recent studies suggest that shorter sleep duration is a risk factor for cardiovascular disease, but there is limited evidence regarding this association using high-quality, objective assessments of sleep. The aim of this study is to determine whether sleep duration is associated with CIMT.
The study used an observational cohort consisting of 617 black and white middle-aged healthy participants (37-52 years; 58% female) in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Multivariable-adjusted linear regression analyses were performed. Sleep duration was measured using wrist actigraphy monitors. CIMT was calculated using the average of 20 measurements of the mean common carotid, bulb, and internal CIMT, which was assessed using ultrasound images.
After adjusting for covariates, 1 hour of longer sleep duration was associated with 0.026 mm less CIMT among men (P=0.02; 95% CI, -0.047 to -0.005) and 0.001 mm less CIMT among women (P=0.91; 95% CI, -0.020 to 0.022). Segment-specific analyses indicated that the carotid bulb was a key driver of the observed association.
Shorter objectively assessed sleep duration was associated with greater CIMT among men but not women.
颈动脉内膜-中层厚度（CIMT）是心血管疾病的一种亚临床标志物。最近的研究表明，睡眠时间较短是心血管疾病的一个危险因素，但关于使用高质量、客观的睡眠评估来评估这种相关性的证据有限。本研究旨在确定睡眠时间是否与 CIMT 相关。
该研究使用了一项观察性队列研究，该研究纳入了 617 名黑人和白人中年健康参与者（37-52 岁；58%为女性），这些参与者来自于年轻人冠状动脉风险发展研究（CARDIA）。采用多变量调整线性回归分析。使用腕部活动监测器来测量睡眠时间。使用超声图像来计算 CIMT，CIMT 是通过 20 次颈总、球部和颈内 CIMT 的平均值计算得出的。
在调整了协变量后，男性睡眠时间每增加 1 小时，CIMT 就会减少 0.026 毫米（P=0.02；95%CI，-0.047 至 -0.005），女性 CIMT 则会减少 0.001 毫米（P=0.91；95%CI，-0.020 至 0.022）。分段特异性分析表明，颈动脉球部是观察到的相关性的关键驱动因素。
在男性中，睡眠时间较短与 CIMT 较大有关，但在女性中则无关。
