Maclure M, Bryant M S, Skipper P L, Tannenbaum S R
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115.
Cancer Res. 1990 Jan 1;50(1):181-4.
The hemoglobin adduct of the human bladder carcinogen 4-aminobiphenyl (4ABP-Hb) declined in the blood of 34 smokers enrolled in a withdrawal program, from a mean of 120 +/- 7 (SE) pg/g of hemoglobin at the start to a mean of 82 +/- 6 pg/g after 3 weeks and a mean of 34 +/- 5 pg/g among the 15 exsmokers who had not resumed smoking after 2 months. Although 4ABP-Hb declined faster than expected under the assumption that the human erythrocyte has a life span of 120 days, it persisted much longer than cotinine. Therefore, 4ABP-Hb may complement the use of cotinine as a marker of exposure to tobacco smoke. The strength of the within-person association of 4ABP-Hb with smoking, coupled with the weakness of the between-person association (correlation coefficient, 0.33), is evidence that between-person variation in modifying factors is substantial. Study of the modifiers of 4ABP-Hb levels may help elucidate the etiology of human susceptibility to aromatic amine-induced bladder cancer.
参与戒烟计划的34名吸烟者血液中人类膀胱致癌物4-氨基联苯的血红蛋白加合物（4ABP-Hb）有所下降，从开始时平均每克血红蛋白120±7（SE）皮克降至3周后的平均82±6皮克，在2个月后仍未恢复吸烟的15名已戒烟者中平均为34±5皮克。尽管假设人类红细胞寿命为120天时，4ABP-Hb下降速度比预期快，但其持续时间比可替宁长得多。因此，4ABP-Hb可补充可替宁作为接触烟草烟雾标志物的用途。4ABP-Hb与吸烟的个体内关联强度，加上个体间关联的薄弱程度（相关系数为0.33），证明修饰因子的个体间差异很大。对4ABP-Hb水平修饰因子的研究可能有助于阐明人类对芳香胺诱导膀胱癌易感性的病因。
