Membrane Biophysics, Max Planck Institute for Intelligent Systems, Stuttgart, Germany.
Cell Death Differ. 2012 Nov;19(11):1733-40. doi: 10.1038/cdd.2012.105. Epub 2012 Aug 31.
The Bcl-2 family of proteins is formed by pro- and antiapoptotic members. Together they regulate the permeabilization of the mitochondrial outer membrane, a key step in apoptosis. Their complex network of interactions both in the cytosol and on mitochondria determines the fate of the cell. In the past 2 decades, the members of the family have been identified and classified according to their function. Several competing models have been proposed to explain how the Blc-2 proteins orchestrate apoptosis signaling. However, basic aspects of the action of these proteins remain elusive. This review is focused on the biophysical mechanisms that are relevant for their action in apoptosis and on the challenging gaps in our knowledge that necessitate further exploration to finally understand how the Bcl-2 family regulates apoptosis.
Bcl-2 蛋白家族由促凋亡和抗凋亡成员组成。它们共同调节线粒体外膜的通透性，这是细胞凋亡的关键步骤。它们在细胞质和线粒体上的复杂相互作用网络决定了细胞的命运。在过去的 20 年中，根据其功能对家族成员进行了鉴定和分类。已经提出了几种竞争模型来解释 Bcl-2 蛋白如何协调细胞凋亡信号。然而，这些蛋白质的作用的基本方面仍然难以捉摸。本综述重点介绍了与它们在细胞凋亡中的作用相关的生物物理机制，以及我们知识中的挑战性差距，这需要进一步探索，以最终了解 Bcl-2 家族如何调节细胞凋亡。
