Department of Pediatrics, Division of Neonatology, Hospital de São João, Porto, Portugal.
J Perinatol. 2013 Apr;33(4):297-301. doi: 10.1038/jp.2012.110. Epub 2012 Aug 30.
To identify variables associated with early nasal continuous positive airway pressure (ENCPAP) failure in preterm neonates less than 30 weeks gestational age.
Multicenter prospective study including 131 preterm newborns, over a period of 2 years. Patients and respiratory variables were assessed using univariate analysis.
Variables associated with ENCPAP failure were: the need of resuscitation with a FiO(2)>0.30; a CPAP pressure of 6.4±1.2 cm H(2)O; the need of a FiO(2) of 0.40 in the first 4 h of life; male gender maintaining the need of a FiO(2)>0.25 in the first 4 h of life; and respiratory distress syndrome with criteria for surfactant administration.
The need for oxygen in resuscitation and maintained in first hours of life, male gender, a CPAP pressure over 5 cm H(2)O and surfactant need are predictors of ENCPAP failure in preterm neonates 26 to 30 weeks gestational age.
确定胎龄小于 30 周的早产儿早期经鼻持续气道正压通气（ENCPAP）失败的相关变量。
这是一项为期 2 年的多中心前瞻性研究，纳入了 131 例早产儿。使用单变量分析评估患者和呼吸变量。
与 ENCPAP 失败相关的变量包括：需要使用 FiO2>0.30 进行复苏；CPAP 压力为 6.4±1.2cmH2O；在生命的前 4 小时需要 FiO20.40；在生命的前 4 小时需要 FiO2>0.25，且为男性；符合表面活性剂给药标准的呼吸窘迫综合征。
复苏时需要吸氧并在生命的前几个小时持续吸氧、男性、CPAP 压力超过 5cmH2O 和需要使用表面活性剂是预测胎龄为 26 至 30 周的早产儿 ENCPAP 失败的预测因素。
