Wanat Karolyn A, Elenitsas Rosalie, Kim Ellen J, Rosenbach Misha
Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Am J Dermatopathol. 2012 Dec;34(8):844-6. doi: 10.1097/DAD.0b013e31825f2606.
Granuloma annulare and other granulomatous disorders have been reported to be associated with internal malignancies, primarily T-cell lymphomas, whereas very few reports of granulomatous disorders in association with B-cell lymphoma exist in the literature. We report a case of marginal zone lymphoma, a cutaneous B-cell lymphoma that occurred concomitantly with refractory granuloma annulare. This case highlights the importance of considering both B- and T-cell dyscrasias in the case of refractory or extensive granulomatous lesions and the importance of histopathologic examination in the evaluation of these lesions.
据报道，环状肉芽肿和其他肉芽肿性疾病与内部恶性肿瘤有关，主要是T细胞淋巴瘤，而文献中关于肉芽肿性疾病与B细胞淋巴瘤相关的报道极少。我们报告一例边缘区淋巴瘤，一种皮肤B细胞淋巴瘤，它与难治性环状肉芽肿同时发生。该病例强调了在难治性或广泛性肉芽肿性病变情况下考虑B细胞和T细胞发育异常的重要性，以及组织病理学检查在评估这些病变中的重要性。
