Janu Lubos, Rackova Sylva, Horacek Jiri
MedAvante Inc., Pilsen, Czech Republic.
Neuro Endocrinol Lett. 2012;33(4):419-24.
The acute and maintenance treatment of alcohol addiction represents the clinical challenge. The aims of our study were to evaluate the influence of alcohol consumption on regional brain metabolism and the predictive value of PET by means of the duration and quality of remission which followed the sub-acute treatment.
PET investigation with 18 fluoro-deoxyglucose (18FDG) were performed in detoxified patients with alcohol dependence at the end of short-term treatment. Abstinence was evaluated in patients during the one year follow-up period.
We detected the positive correlation between 18FDG uptake in the cerebellar vermis (FWE, p<0.05) and duration of abstinence within one year.
Our findings support the assumption that the cerebellum would be involved in the maintenance of abstinence in alcohol dependent subjects. Cerebellar connections with cortical areas critical for addiction such as frontal, parietal, temporal regions would mediate the influence of the cerebellum on emotional systems related to addiction.
Our study is the first to document that the cerebellum and particularly the vermis is involved in the clinical outcome in terms of abstinence during one year. Our findings support the role of the cerebellum in addiction and the possibility to predict therapeutic outcome.
酒精成瘾的急性和维持治疗是一项临床挑战。我们研究的目的是通过亚急性治疗后的缓解持续时间和质量，评估饮酒对脑区代谢的影响以及正电子发射断层扫描（PET）的预测价值。
在短期治疗结束时，对戒酒的酒精依赖患者进行18氟脱氧葡萄糖（18FDG）PET检查。在患者一年的随访期内评估戒酒情况。
我们检测到小脑蚓部的18FDG摄取与一年内的戒酒持续时间之间存在正相关（FWE，p<0.05）。
我们的研究结果支持这样一种假设，即小脑参与酒精依赖者的戒酒维持。小脑与对成瘾至关重要的皮质区域（如额叶、顶叶、颞叶区域）的连接将介导小脑对与成瘾相关的情绪系统的影响。
我们的研究首次证明小脑尤其是蚓部在一年戒酒方面参与了临床结果。我们的研究结果支持小脑在成瘾中的作用以及预测治疗结果的可能性。
