Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.
Chem Commun (Camb). 2012 Oct 14;48(80):10043-5. doi: 10.1039/c2cc34217k.
Fractalkine (FKN) is a unique cell surface protein with potential as a therapeutic target because of its role in inflammatory diseases and cancer. We developed an aptamer, named FKN-S2, with a dissociation constant of 3.4 ± 0.7 nM that is specific to the chemokine domain of fractalkine.
趋化因子（FKN）是一种独特的细胞表面蛋白，由于其在炎症性疾病和癌症中的作用，具有成为治疗靶点的潜力。我们开发了一种适体，命名为 FKN-S2，其解离常数为 3.4 ± 0.7 nM，对趋化因子结构域的趋化因子具有特异性。
