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发育。食管干细胞,你在哪里?

Development. Esophageal stem cells, where art thou?

机构信息

McNair Medical Institute, Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Houston, TX 77030, USA.

出版信息

Science. 2012 Aug 31;337(6098):1051-2. doi: 10.1126/science.1227506.

DOI:10.1126/science.1227506
PMID:22936766
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3762587/
Abstract

The lumen of the esophagus is lined with a squamous stratified epithelium. In the model of Doupé . (based on the mouse esophageal epithelium), a single population of epithelial progenitor cells (yellow) is present above the basal lamina. The epithelium is maintained, under basal conditions, by these cells, which divide and produce both more progenitor cells or differentiate into the layers of the stratified epithelium

摘要

食管的管腔衬有鳞状分层上皮。在 Doupé 的模型中(基于小鼠食管上皮),基底膜上方存在单一的上皮祖细胞群体(黄色)。在基础条件下,上皮由这些细胞维持,这些细胞分裂并产生更多的祖细胞或分化为分层上皮的层。

相似文献

1
Development. Esophageal stem cells, where art thou?发育。食管干细胞,你在哪里?
Science. 2012 Aug 31;337(6098):1051-2. doi: 10.1126/science.1227506.
2
A single progenitor population switches behavior to maintain and repair esophageal epithelium.单一祖细胞群体转变行为以维持和修复食管上皮。
Science. 2012 Aug 31;337(6098):1091-3. doi: 10.1126/science.1218835. Epub 2012 Jul 19.
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Morfologiia. 2006;129(3):7-21.
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Cycling progenitors maintain epithelia while diverse cell types contribute to repair.成体干细胞在维持上皮组织的同时,多种细胞类型也有助于组织修复。
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Beyond the niche: tissue-level coordination of stem cell dynamics.超越利基:干细胞动态的组织层面协调。
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引用本文的文献

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Circulating Tumor Cells in the Adenocarcinoma of the Esophagus.食管腺癌中的循环肿瘤细胞
Int J Mol Sci. 2016 Aug 4;17(8):1266. doi: 10.3390/ijms17081266.
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Deoxycholic acid (DCA) confers an intestinal phenotype on esophageal squamous epithelium via induction of the stemness-associated reprogramming factors OCT4 and SOX2.脱氧胆酸(DCA)通过诱导与干性相关的重编程因子OCT4和SOX2,使食管鳞状上皮呈现肠道表型。
Cell Cycle. 2016 Jun 2;15(11):1439-49. doi: 10.1080/15384101.2016.1175252. Epub 2016 Apr 20.
3
Murine and human tissue-engineered esophagus form from sufficient stem/progenitor cells and do not require microdesigned biomaterials.小鼠和人类组织工程食管由足够的干细胞/祖细胞形成,不需要微设计的生物材料。
Tissue Eng Part A. 2015 Mar;21(5-6):906-15. doi: 10.1089/ten.TEA.2014.0357. Epub 2014 Nov 20.

本文引用的文献

1
A single progenitor population switches behavior to maintain and repair esophageal epithelium.单一祖细胞群体转变行为以维持和修复食管上皮。
Science. 2012 Aug 31;337(6098):1091-3. doi: 10.1126/science.1218835. Epub 2012 Jul 19.
2
Stem cells in gastroenterology and hepatology.胃肠病学和肝脏病学中的干细胞。
Nat Rev Gastroenterol Hepatol. 2009 Dec;6(12):724-37. doi: 10.1038/nrgastro.2009.195. Epub 2009 Nov 3.
3
A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification.小鼠食管基底细胞的一个亚群具有干细胞特性,具备自我更新和谱系定向分化的能力。
J Clin Invest. 2008 Dec;118(12):3860-9. doi: 10.1172/JCI35012. Epub 2008 Nov 6.
4
Esophageal stem cells--a review of their identification and characterization.食管干细胞——其鉴定与特征综述
Stem Cell Rev. 2008 Dec;4(4):261-8. doi: 10.1007/s12015-008-9031-3. Epub 2008 Aug 5.
5
A single type of progenitor cell maintains normal epidermis.单一类型的祖细胞维持正常表皮。
Nature. 2007 Mar 8;446(7132):185-9. doi: 10.1038/nature05574. Epub 2007 Feb 28.
6
Neurotrophin receptor p75(NTR) characterizes human esophageal keratinocyte stem cells in vitro.神经营养因子受体p75(NTR)在体外可鉴定人食管角质形成干细胞。
Oncogene. 2003 Jun 26;22(26):4017-26. doi: 10.1038/sj.onc.1206525.
7
Asymmetric stem-cell divisions define the architecture of human oesophageal epithelium.不对称干细胞分裂决定了人类食管上皮的结构。
Curr Biol. 2000 Nov 16;10(22):1447-50. doi: 10.1016/s0960-9822(00)00803-4.