发育。食管干细胞，你在哪里？
Development. Esophageal stem cells, where art thou?
机构信息
McNair Medical Institute, Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Science. 2012 Aug 31;337(6098):1051-2. doi: 10.1126/science.1227506.
Abstract
The lumen of the esophagus is lined with a squamous stratified epithelium. In the model of Doupé . (based on the mouse esophageal epithelium), a single population of epithelial progenitor cells (yellow) is present above the basal lamina. The epithelium is maintained, under basal conditions, by these cells, which divide and produce both more progenitor cells or differentiate into the layers of the stratified epithelium
摘要
食管的管腔衬有鳞状分层上皮。在 Doupé 的模型中（基于小鼠食管上皮），基底膜上方存在单一的上皮祖细胞群体（黄色）。在基础条件下，上皮由这些细胞维持，这些细胞分裂并产生更多的祖细胞或分化为分层上皮的层。
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A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification.小鼠食管基底细胞的一个亚群具有干细胞特性，具备自我更新和谱系定向分化的能力。
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