The Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, UK.
Bioessays. 2013 May;35(5):443-51. doi: 10.1002/bies.201200166. Epub 2013 Mar 6.
It has recently been shown that stem and progenitor cells undergo population self-renewal to maintain epithelial homeostasis. The fate of individual cells is stochastic but the production of proliferating and differentiating cells is balanced across the population. This new paradigm, originating in mouse epidermis and since extended to mouse oesophagus and mouse and Drosophila intestine, is in contrast to the long held model of epithelial maintenance by exclusively asymmetric division of stem cells. Recent lineage tracing studies have now shown that wound responses vary between tissues, and that a stem cell reserve is not essential as cycling progenitors and even differentiating cells contribute to regeneration.
最近已经表明，干细胞和祖细胞通过群体自我更新来维持上皮组织的稳态。虽然单个细胞的命运是随机的，但增殖和分化细胞的产生在整个群体中是平衡的。这一新的范例源于小鼠表皮，随后扩展到小鼠食管、小鼠和果蝇肠道，与长期以来认为的上皮组织通过干细胞的不对称分裂来维持的模型相反。最近的谱系追踪研究表明，组织之间的伤口反应存在差异，而且干细胞储备并不是必需的，因为循环祖细胞甚至分化细胞都有助于再生。
