维生素 D、甲状旁腺激素及其与中国人群高血压的相关性。
Vitamin D, parathyroid hormone and their associations with hypertension in a Chinese population.
机构信息
Department of Internal Medicine, Dali University School of Medicine, Dali, Yunnan Province, China.
出版信息
PLoS One. 2012;7(8):e43344. doi: 10.1371/journal.pone.0043344. Epub 2012 Aug 16.
BACKGROUND
Conflicting reports support or refute an association between vitamin D deficiency with high levels of parathyroid hormone (PTH) and raised blood pressure or hypertension.
OBJECTIVE
To explore the associations of serum vitamin D and PTH levels with blood pressure and risk of hypertension in a Chinese population.
METHODS
A population-based cross-sectional study was conducted among 1,420 Chinese participants, aged 20-83 years, in 2010. Anthropometric phenotypes and blood pressure were evaluated. Serum lipids, 25-hydroxyvitamin D [25(OH)D] and PTH were measured.
RESULTS
One thousand four hundred and twenty participants, including 566 women (39.9%), were evaluated in 2010. Four hundred and eighty seven were hypertensive (34.3%), of whom 214 (43.9%) received antihypertensive treatment. The median concentrations of serum 25(OH)D and PTH were 22.0 ng/ml and 2.83 pmol/l, respectively. Serum 25(OH)D and natural log of PTH levels were not independently associated with blood pressure in a multivariable adjusted linear regression analysis of 1,206 participants not receiving antihypertensive treatment (P>0.05). In logistic regression analyses, serum 25(OH)D levels were not associated with risk of hypertension in single and multiple regression models. One unit increments of natural log of PTH levels were significantly associated with risk of hypertension in the crude model (OR = 1.78, 95% confidence interval 1.38-2.28, P<0.0001) and model adjusted for age and sex (OR = 1.41, 95% confidence interval 1.08-1.83, P = 0.01). However, these associations were attenuated and became nonsignificant (OR = 1.29, 95% confidence interval 0.98-1.70, P = 0.07) after further adjustment for body mass index, current alcohol intake, current smoking, glomerular filtration rate and family history of hypertension.
CONCLUSIONS
Serum vitamin D and PTH levels are not independently associated with blood pressure or risk of hypertension in a Chinese population.
背景
一些报告支持，而另一些报告则否定了维生素 D 缺乏与甲状旁腺激素（PTH）水平升高以及血压升高或高血压之间的关系。
目的
在中国人中探索血清维生素 D 和 PTH 水平与血压和高血压风险之间的关系。
方法
2010 年进行了一项基于人群的横断面研究，共纳入 1420 名年龄在 20-83 岁的中国参与者。评估了人体测量表型和血压。测量了血清脂质、25-羟维生素 D [25(OH)D] 和 PTH。
结果
2010 年共评估了 1420 名参与者，其中包括 566 名女性（39.9%）。487 名参与者患有高血压（34.3%），其中 214 名（43.9%）接受了降压治疗。血清 25(OH)D 和 PTH 的中位数浓度分别为 22.0ng/ml 和 2.83pmol/l。在未接受降压治疗的 1206 名参与者的多变量调整线性回归分析中，血清 25(OH)D 和自然对数 PTH 水平与血压无独立相关性（P＞0.05）。在逻辑回归分析中，血清 25(OH)D 水平与单因素和多因素回归模型中的高血压风险均无关联。自然对数 PTH 水平每增加一个单位，在未校正模型（OR=1.78，95%置信区间 1.38-2.28，P＜0.0001）和校正年龄和性别后的模型（OR=1.41，95%置信区间 1.08-1.83，P=0.01）中，与高血压风险显著相关。然而，在进一步调整体重指数、当前饮酒量、当前吸烟、肾小球滤过率和高血压家族史后，这些相关性减弱且变得无统计学意义（OR=1.29，95%置信区间 0.98-1.70，P=0.07）。
结论
在中国人中，血清维生素 D 和 PTH 水平与血压或高血压风险无独立相关性。
Zotero 插件