Department of Physiology, School of Medical Sciences, Bosch Institute, The University of Sydney, Sydney, Australia.
Macao Hypertension League, Macao, China.
PLoS One. 2020 Mar 4;15(3):e0229642. doi: 10.1371/journal.pone.0229642. eCollection 2020.
Chinese women are known to have both a high prevalence of metabolic syndrome (MetS) and vitamin D deficiency (serum 25-hydroxyvitamin D (25OHD) <50 nmol/l). Associations between sleep duration and circulating 25OHD have recently been reported but, to our knowledge, these associations have not been studied in older Chinese populations. We thus investigated whether sleep duration was associated with vitamin D status in a population from Macao, China, and whether sleep duration modified the association between MetS and vitamin D deficiency. In 207 older (>55 years) Macanese, anthropometry, blood samples and validated questionnaires, including sleep duration and cardiovascular risk factors, were simultaneously collected. On multivariable categorical analyses, those women, not men, who had short sleep duration (≤6 hours (h)) were at a 2-fold risk for vitamin D deficiency (both <50 nmol/L and <37 nmol/L; OR = 1.94, 95%CI 1.29-2.92; OR = 2.05, 95%CI 1.06-3.98, respectively) and those who had longer sleep duration (>8 h) were 3-fold more likely to have vitamin D deficiency (OR = 3.07, 95%CI 1.47-6.39; OR = 2.75, 95%CI 1.08-7.00, respectively) compared to those with normal sleep duration (6-8 h). Both women and men with MetS were 2-fold more likely to have vitamin D deficiency (women: OR = 2.04, 95%CI 1.31-3.17; OR = 2.15, 95%CI 1.11-4.17, respectively; men: OR = 2.01, 95%CI 1.23-3.28; OR = 2.04, 95%CI 1.00-4.29, respectively). Moreover, women with both short sleep duration and MetS had an increased risk of vitamin D deficiency (OR = 3.26, 95%CI 1.10-9.64). These associations were not found in those with longer sleep. Men with longer sleep and MetS had a 5-fold risk of vitamin D deficiency (OR = 5.22; 95%CI 2.70-10.12). This association was non-significant for men with shorter sleep. We conclude that both short and long sleep duration were associated with vitamin D deficiency in older Chinese women. Further research is needed in larger cohorts or with intervention studies to further examine the associations between reduced sleep, metabolic syndrome and vitamin D deficiency.
中国女性代谢综合征（MetS）和维生素 D 缺乏症（血清 25-羟维生素 D（25OHD）<50nmol/L）的患病率均较高。最近有研究报道了睡眠时长与循环 25OHD 之间的关系，但据我们所知，这些关系尚未在年龄较大的中国人群中进行研究。因此，我们研究了澳门老年人群（>55 岁）中睡眠时长与维生素 D 状态之间的关系，以及睡眠时长是否会改变 MetS 与维生素 D 缺乏症之间的关系。在 207 名澳门老年人（>55 岁）中，同时采集了人体测量学、血液样本和经过验证的问卷，包括睡眠时长和心血管危险因素。在多变量分类分析中，与睡眠时长 6-8 小时的女性相比，睡眠时长较短（≤6 小时）的女性维生素 D 缺乏症的风险增加了两倍（<50nmol/L 和<37nmol/L；OR=1.94，95%CI 1.29-2.92；OR=2.05，95%CI 1.06-3.98），而睡眠时长较长（>8 小时）的女性维生素 D 缺乏症的风险增加了三倍（OR=3.07，95%CI 1.47-6.39；OR=2.75，95%CI 1.08-7.00）。与睡眠时长正常（6-8 小时）的女性相比，患有 MetS 的女性发生维生素 D 缺乏症的风险增加了两倍（女性：OR=2.04，95%CI 1.31-3.17；OR=2.15，95%CI 1.11-4.17）。患有 MetS 的男性发生维生素 D 缺乏症的风险也增加了两倍（男性：OR=2.01，95%CI 1.23-3.28；OR=2.04，95%CI 1.00-4.29）。此外，睡眠时长较短且患有 MetS 的女性发生维生素 D 缺乏症的风险增加（OR=3.26，95%CI 1.10-9.64）。这些关联在睡眠较长的人群中并未发现。睡眠较长且患有 MetS 的男性发生维生素 D 缺乏症的风险增加 5 倍（OR=5.22；95%CI 2.70-10.12）。而睡眠较短且患有 MetS 的男性则没有这种关联。我们得出结论，短时间和长时间睡眠都与中国老年女性维生素 D 缺乏症有关。需要在更大的队列中或通过干预研究进一步研究睡眠时间减少、代谢综合征和维生素 D 缺乏症之间的关系。
