Newton Herbert B
Neuro-Oncology Center and Brain Tumor Institute, University Hospitals of Cleveland Medical Center, Seidman Cancer Center, Cleveland, Ohio, USA; Molecular Oncology Program, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
J Ayurveda Integr Med. 2024 Jul-Aug;15(4):101013. doi: 10.1016/j.jaim.2024.101013. Epub 2024 Aug 23.
Ayurveda is the traditional medicine system of India, and has been in practice for millennia. It is a traditional approach that uses 1000's of different plant preparations in various combinations for treatment of human ailments, including cancer. Ethnopharmacological and phytochemical analyses are now elucidating the bioactive constituents of the different plant species and herbal formulations, including ashwagandha, curcumin, guduchi, triphala, and others. To provide an overview of: 1) the ethnopharmacology of Ayurveda and several of its most important plant species and formulations, including pharmacological and molecular mechanisms of its anti-cancer effects; 2) review the literature applying Ayurvedic herbs and formulations to brain tumors. A detailed PubMed search was performed that included publications involving Ayurveda, cancer, ethnopharmacology, phytochemical analysis, molecular analysis, and brain tumors. In recent decades, significant research has begun to elucidate the bioactive compounds of ashwagandha, tumeric, guduchi, and triphala, such as withaferin A, withanolides, curcumin, palmatine, and many others. These compounds and extracts are now being applied to brain tumor cells in vitro and in animal models, with positive signs of anti-cancer activity including reduced cell growth, increased apoptosis, cell cycle arrest, increased differentiation, and inhibition of important internal signal transduction pathways. Several Ayurvedic herbs (ashwagandha, curcumin) have bioactive compounds with significant anti-cancer activity, and are effective in early pre-clinical testing against brain tumor cells in vitro and in animal models. Further pre-clinical testing is warranted, along with advancement into phase I and phase II clinical trials of patients with glioblastoma and other brain tumors.
阿育吠陀是印度的传统医学体系，已沿用了数千年。它是一种传统疗法，使用数千种不同的植物制剂以各种组合方式来治疗人类疾病，包括癌症。民族药理学和植物化学分析如今正在阐明不同植物物种和草药配方（包括印度人参、姜黄素、印度藤黄、三果木等）的生物活性成分。目的是概述：1）阿育吠陀及其几种最重要的植物物种和配方的民族药理学，包括其抗癌作用的药理和分子机制；2）综述将阿育吠陀草药和配方应用于脑肿瘤的文献。进行了详细的PubMed搜索，其中包括涉及阿育吠陀、癌症、民族药理学、植物化学分析、分子分析和脑肿瘤的出版物。近几十年来，大量研究已开始阐明印度人参、姜黄、印度藤黄和三果木的生物活性化合物，如白屈菜红碱、睡茄内酯、姜黄素、巴马汀等。这些化合物和提取物现在正被应用于体外脑肿瘤细胞和动物模型中，显示出抗癌活性的积极迹象，包括细胞生长减少、细胞凋亡增加、细胞周期停滞、分化增加以及重要内部信号转导通路的抑制。几种阿育吠陀草药（印度人参、姜黄素）具有具有显著抗癌活性的生物活性化合物，并且在针对体外脑肿瘤细胞和动物模型的早期临床前测试中有效。有必要进行进一步的临床前测试，并推进到胶质母细胞瘤和其他脑肿瘤患者的I期和II期临床试验。
