Hurtado-Cordovi Jorge M, Verma Vaibhav, Gotlieb Vladimir, Frieri Marianne
Divisions of Hematology and Oncology and Allergy and Immunology, Department of Medicine, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, USA.
Case Rep Hematol. 2011;2011:385408. doi: 10.1155/2011/385408. Epub 2011 Sep 28.
Hodgkin's lymphoma accounts for ten percent of all lymphomas. In the United States, there are about 8000 new cases every year. This paper describes a case of lymphocyte-rich Hodgkin's lymphoma (LRHL) manifested by autoimmune hemolytic anemia (AIHA). A 27-year-old Israeli male presented with dizziness associated with one month of low-grade fevers and night sweats; he also complained of persistent cough, pruritus, and ten-pound weight lost during this time. The CBC revealed hemoglobin of 5.9 gm/dL, and direct Coomb's test detected multiple nonspecific antibodies consistent with the diagnosis of AIHA. Chest, abdomen, and pelvic CT scan showed mediastinal lymphadenopathy and splenomegaly. Lymph node biopsy revealed classic LRHL. AIHA resolved after completion of the first cycle of chemotherapy with adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD); after six cycles, he went into complete remission. Although infrequent, AIHA can be responsible for the presenting symptoms of HL.
霍奇金淋巴瘤占所有淋巴瘤的10%。在美国，每年约有8000例新发病例。本文描述了一例以自身免疫性溶血性贫血（AIHA）为表现的富于淋巴细胞型霍奇金淋巴瘤（LRHL）。一名27岁的以色列男性出现头晕，伴有1个月的低热和盗汗；他还诉说在此期间持续咳嗽、瘙痒，体重减轻了10磅。血常规显示血红蛋白为5.9 gm/dL，直接抗人球蛋白试验检测到多种非特异性抗体，符合AIHA的诊断。胸部、腹部和盆腔CT扫描显示纵隔淋巴结肿大和脾肿大。淋巴结活检显示为典型的LRHL。使用阿霉素、博来霉素、长春花碱和达卡巴嗪（ABVD）完成第一个化疗周期后，AIHA得到缓解；六个周期后，他进入完全缓解期。虽然不常见，但AIHA可能是HL首发症状的原因。
