Pullen S J, Wall C A, Lee K H, Stead S M, Klassen B T, Brown T M
Department of Psychiatry and Psychology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Case Rep Neurol Med. 2011;2011:209467. doi: 10.1155/2011/209467. Epub 2011 Oct 19.
This case study followed one adolescent patient who underwent bilateral deep brain stimulation of the centromedian parafascicular complex (CM-Pf) for debilitating, treatment refractory Tourette's syndrome for a period of 1.5 years. Neurocognitive testing showed no significant changes between baseline and follow-up assessments. Psychiatric assessment revealed positive outcomes in overall adaptive functioning and reduction in psychotropic medication load in this patient. Furthermore, despite significant baseline psychiatric comorbidity, this patient reported no suicidal ideation following electrode implantation. Deep brain stimulation is increasingly being used in children and adolescents. This case reports on the positive neurologic and neuropsychiatric outcome of an adolescent male with bilateral CM-Pf stimulation.
本案例研究跟踪了一名青少年患者，该患者因严重的、治疗难治性抽动秽语综合征接受了双侧中央中核-束旁复合体（CM-Pf）深部脑刺激治疗，为期1.5年。神经认知测试显示，基线评估和随访评估之间没有显著变化。精神病学评估显示，该患者在整体适应性功能方面取得了积极成果，且精神药物负荷有所降低。此外，尽管该患者基线时存在显著的精神疾病共病情况，但在电极植入后未报告有自杀意念。深部脑刺激在儿童和青少年中的应用越来越广泛。本案例报告了一名接受双侧CM-Pf刺激的青少年男性在神经学和神经精神病学方面的积极结果。
