Kelsall H L, Sim M R, Forbes A B, Glass D C, McKenzie D P, Ikin J F, Abramson M J, Blizzard L, Ittak P
Department of Epidemiology and Preventive Medicine, Monash University-Central and Eastern Clinical School, Alfred Hospital, Commercial Road, Melbourne, Victoria, Australia.
Occup Environ Med. 2004 Dec;61(12):1006-13. doi: 10.1136/oem.2003.009258.
To investigate whether Australian Gulf War veterans have a higher than expected prevalence of recent symptoms and medical conditions that were first diagnosed in the period following the 1991 Gulf War; and if so, whether these effects were associated with exposures and experiences that occurred in the Gulf War.
Cross-sectional study of 1456 Australian Gulf War veterans and a comparison group who were in operational units at the time of the Gulf War, but were not deployed to that conflict (n = 1588). A postal questionnaire was administered and the likelihood of the diagnosis of self-reported medical conditions was assessed and rated by a medical practitioner.
Gulf War veterans had a higher prevalence of all self-reported health symptoms than the comparison group, and more of the Gulf War veterans had severe symptoms. Increased symptom reporting was associated with several exposures, including having more than 10 immunisations, pyridostigmine bromide tablets, anti-biological warfare tablets, pesticides, insect repellents, reportedly being in a chemical weapons area, and stressful military service experiences in a strong dose-response relation. Gulf War veterans reported psychological (particularly post-traumatic stress disorder), skin, eye, and sinus conditions first diagnosed in 1991 or later more commonly than the comparison group. Over 90% of medical conditions reported by both study groups were rated by a medical practitioner as having a high likelihood of diagnosis.
More than 10 years after the 1991 Gulf War, Australian veterans self-report all symptoms and some medical conditions more commonly than the comparison group. Further analysis of the severity of symptoms and likelihood of the diagnosis of medical conditions suggested that these findings are not due to over-reporting or to participation bias.
调查澳大利亚海湾战争退伍军人近期首次诊断出的症状和疾病患病率是否高于预期,这些症状和疾病首次出现在1991年海湾战争之后;如果是这样,这些影响是否与海湾战争期间的接触和经历有关。
对1456名澳大利亚海湾战争退伍军人以及一个对照组进行横断面研究,对照组是在海湾战争期间在作战部队但未被部署到该冲突地区的人员(n = 1588)。通过邮寄问卷进行调查,并由一名医生评估和评定自我报告的疾病诊断可能性。
海湾战争退伍军人自我报告的所有健康症状患病率均高于对照组,且更多海湾战争退伍军人有严重症状。症状报告增加与多种接触有关,包括接种超过10次疫苗、服用溴吡斯的明片、服用防生物战药片、接触杀虫剂、驱虫剂、据报道身处化学武器区域以及高强度应激的军事服役经历,呈现出强剂量反应关系。海湾战争退伍军人报告的心理(尤其是创伤后应激障碍)、皮肤、眼睛和鼻窦疾病首次诊断于1991年或之后的情况比对照组更为常见。两个研究组报告的疾病中,超过90%被医生评定为诊断可能性高。
在1991年海湾战争过去10多年后,澳大利亚退伍军人自我报告的所有症状和一些疾病比对照组更为常见。对症状严重程度和疾病诊断可能性的进一步分析表明,这些发现并非由于报告过度或参与偏倚所致。