Chibishev Andon, Pareska Zenina, Chibisheva Vesna, Simonovska Natasa
University Clinic of Toxicology, Clinical Centre Skopje, Republic of Macedonia.
Med Arch. 2012;66(3 Suppl 1):11-5. doi: 10.5455/medarh.2012.66.s11-s15.
the ingestion of chemical agents, of caustic nature, represents a serious problem for clinical toxicology. If the ingestion doesn't cause death during the acute period, it will most often cause severe side effects in the upper gastrointestinal tract during the chronic phase.
The purpose of this study is to show the clinical, epidemiological and socio-economical characteristics seen in acute corrosive poisonings such as ingested caustic agents, causes for abuse and most consequential complications.
a ten year medical data was constructed and collected (2000-2009) from patients with acute corrosive poisonings who were hospitalized and treated in the University Clinic of toxicology and urgent internal medicine in Skopje, Republic of Macedonia. The variables included were: age, sex, type of poisonings and percentage of late post-corrosive complications.
In the study, 735 patients files were analyzed, collected in a period often years. The mean age of patients is 32.9 +/- 15.6 years. Majority of patients ingested hydrochloric acid (HCl; n = 354; 48,16%).
Demographic, diagnostic and therapeutic findings in acute corrosive poisonings are found to be similar to the findings observed in the referenced literature. Conclusively, women between 14 and 30 years old represent a high risk group; hydrochloric acid is the most often abused agent; and high percentage of post-corrosive complications are
摄入具有腐蚀性的化学制剂是临床毒理学面临的一个严重问题。如果在急性期摄入未导致死亡，那么在慢性期通常会在上消化道引发严重的副作用。
本研究的目的是展示急性腐蚀性中毒（如摄入腐蚀性制剂）的临床、流行病学和社会经济特征、滥用原因以及最常见的并发症。
构建并收集了十年（2000 - 2009年）间在马其顿共和国斯科普里大学毒理学与急诊内科住院治疗的急性腐蚀性中毒患者的医疗数据。纳入的变量包括：年龄、性别、中毒类型以及腐蚀性后期并发症的发生率。
在该研究中，分析了在十年期间收集的735份患者档案。患者的平均年龄为32.9 ± 15.6岁。大多数患者摄入的是盐酸（HCl；n = 354；48.16%）。
急性腐蚀性中毒的人口统计学、诊断和治疗结果与参考文献中的观察结果相似。总之，14至30岁的女性是高危人群；盐酸是最常被滥用的制剂；并且腐蚀性后期并发症的发生率很高。
