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腐蚀性物质摄入的临床流行病学特征:巴基斯坦旁遮普省南部木尔坦一家三级护理医院的横断面研究

Clinico-epidemiological Characteristics of Corrosive Ingestion: A Cross-sectional Study at a Tertiary Care Hospital of Multan, South-Punjab Pakistan.

作者信息

Hashmi Muhammad Usman, Ali Mansoor, Ullah Kaleem, Aleem Abdul, Khan Iftikhar H

机构信息

Thoracic Surgery, Nishtar Medical University Hospital, Multan, PAK.

Upper Gi and Thoracic Surgery, Nishtar Medical University Hospital, Multan, PAK.

出版信息

Cureus. 2018 May 29;10(5):e2704. doi: 10.7759/cureus.2704.

DOI:10.7759/cureus.2704
PMID:30062078
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6063384/
Abstract

Introduction Corrosive ingestion is a grave public health problem. It is a medical emergency and shows diverse clinical presentations. The ingestion of corrosive substances has devastating effects on upper gastrointestinal and respiratory tracts and the corrosive injury is associated with numerous life-threatening complications. The present study aims to explore the clinico-epidemiological characteristics of patients of corrosive ingestion presenting at a tertiary care hospital of Multan, Pakistan. Method The target study population consists of all the patients with primary diagnosis of corrosive ingestion who presented to the department of thoracic surgery, Nishtar Medical University Hospital Multan, Pakistan, from January 2016 to December 2017. The follow-up cases and the cases with ingestion of substances other than corrosives were not included in the study. All the included cases were evaluated by detailed history, thorough physical examination and the necessary investigations. The post-cor-rosive tissue damage was classified accord-ing to Zargar's classification system. All the demographic data and other variables were measured and recorded using a Performa. The data were analyzed by using computer program SPSS 21 version. Results The total study population was 206 patients. There were 135 females (65.5%) and 71 male patients (34.5%). Age ranged from 2 to 42 years (mean 23.44 ± 7.19). Only seven cases were found in the age group of 2-7 years. The residents of rural areas showed a slightly increased inclination towards corrosive ingestion. One hundred and ten cases were unmarried (53.4%) while 90 patients were married (43.7%). The incidence of corrosive ingestion was much high in illiterate/less educated patients belonging to the groups of lower socio-economic status. One hundred and ninety-seven patients ingested corrosive substances deliberately with the suicidal intention (95.6%). The acid used as bathroom cleaner and the laundry bleaches were the most commonly used corrosive agents. In 166 cases the corrosive materials were already present at home for domestic purposes (80.6%), but 18 subjects particularly purchased these corrosive substances to commit suicide. The quantity of ingested material ranged between 10 ml and 150 ml with a mean of 42.6 ml ± 33.2. The shortest hospital stay was one day, and the longest one was 60 days. Esophagus and oropharyngeal area were the most common site which sustained the corrosive injury, whereas corrosive injury to duodenum was least frequent (34.5 %). Conclusion Corrosive ingestion is a serious medical problem and it requires a multidisciplinary approach and a good coordination between different medical specialists. Underprivileged teenager females of rural areas are more likely to ingest corrosive materials with suicidal intention. In most of the ingestions, household cleaning products are used. Only the patients with severe corrosive injury should be admitted to intensive care units. Enforcing regulations for the manufacturers of household cleaning products can significantly reduce the incidence of this potentially fatal condition.

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb06/6063384/a7b1b79f0040/cureus-0010-00000002704-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb06/6063384/a7b1b79f0040/cureus-0010-00000002704-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb06/6063384/a7b1b79f0040/cureus-0010-00000002704-i01.jpg
摘要

引言 腐蚀性物质摄入是一个严重的公共卫生问题。它是一种医疗急症,临床表现多样。腐蚀性物质的摄入对上消化道和呼吸道具有毁灭性影响,且腐蚀性损伤会引发众多危及生命的并发症。本研究旨在探讨在巴基斯坦木尔坦一家三级护理医院就诊的腐蚀性物质摄入患者的临床流行病学特征。

方法 目标研究人群包括2016年1月至2017年12月期间在巴基斯坦木尔坦尼什塔尔医科大学医院胸外科就诊的所有原发性腐蚀性物质摄入患者。随访病例以及摄入腐蚀性物质以外其他物质的病例不包括在本研究中。所有纳入病例均通过详细病史、全面体格检查及必要检查进行评估。腐蚀性物质摄入后的组织损伤根据扎尔加分类系统进行分类。所有人口统计学数据及其他变量均使用一份表格进行测量和记录。数据采用计算机程序SPSS 21版进行分析。

结果 研究总人群为206例患者。其中女性135例(65.5%),男性71例(34.5%)。年龄范围为2至42岁(平均23.44±7.19岁)。2至7岁年龄组仅发现7例。农村地区居民腐蚀性物质摄入倾向略有增加。110例未婚(53.4%),90例已婚(43.7%)。社会经济地位较低的文盲/受教育程度较低患者腐蚀性物质摄入发生率较高。197例患者故意摄入腐蚀性物质以自杀(95.6%)。用作浴室清洁剂的酸和洗衣漂白剂是最常用的腐蚀性物质。166例中腐蚀性物质已在家中用于家庭用途(80.6%),但18名受试者特意购买这些腐蚀性物质用于自杀。摄入物质的量在10毫升至150毫升之间,平均为42.6毫升±33.2毫升。最短住院天数为1天,最长为60天。食管和口咽区域是腐蚀性损伤最常见的部位,而十二指肠腐蚀性损伤最少见(34.5%)。

结论 腐蚀性物质摄入是一个严重的医疗问题,需要多学科方法以及不同医学专家之间的良好协作。农村地区贫困青少年女性更有可能出于自杀意图摄入腐蚀性物质。在大多数摄入情况中,使用的是家用清洁产品。仅严重腐蚀性损伤患者应入住重症监护病房。对家用清洁产品制造商实施监管可显著降低这种潜在致命状况的发生率。

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