Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA 94305-5719, USA.
Bipolar Disord. 2012 Sep;14(6):585-96. doi: 10.1111/j.1399-5618.2012.01043.x.
A range of prefrontal and subcortical volumetric abnormalities have been found in adults and adolescents with bipolar disorder. It is unclear, however, if these deficits are present early in the onset of mania or are a consequence of multiple mood episodes or prolonged exposure to medication. The goal of this study was to examine whether youth with bipolar I disorder who recently experienced their first episode of mania are characterized by brain volumetric abnormalities.
Anatomical images from magnetic resonance imaging of 26 13- to 18-year-old adolescents with bipolar I disorder and 24 age-comparable healthy controls with no personal or family history of psychopathology were analyzed using whole-brain voxel-based morphometry (VBM).
Compared with healthy controls, adolescents with bipolar I disorder had significantly less gray matter volume in the left subgenual cingulate cortex [p<0.05, family-wise error (FWE)-corrected].
Adolescents with a recent single episode of mania have smaller subgenual cingulate cortex volume than do their healthy counterparts, suggesting that this anomaly occurs early in the onset of, or may predate the disorder. Longitudinal studies are needed to examine the impact of this volumetric reduction on the course and outcome of this disorder.
在成年和青少年双相情感障碍患者中发现了一系列前额叶和皮质下体积异常。然而，目前尚不清楚这些缺陷是在躁狂发作早期出现的，还是多次情绪发作或长期药物暴露的结果。本研究的目的是检查最近经历首次躁狂发作的青少年双相 I 型障碍患者是否存在脑体积异常。
对 26 名 13 至 18 岁的青少年双相 I 型障碍患者和 24 名年龄匹配的无精神病史或家族史的健康对照者的磁共振成像进行了全脑基于体素的形态测量学（VBM）分析。
与健康对照组相比，青少年双相 I 型障碍患者左侧扣带回亚皮质的灰质体积明显减少[p<0.05，经家族性错误（FWE）校正]。
最近出现单次躁狂发作的青少年患者的扣带回亚皮质体积较小，这表明这种异常发生在疾病发作的早期，或者可能早于疾病的发生。需要进行纵向研究，以检查这种体积减少对该疾病病程和结果的影响。
