Mitsunaga Myles M, Garrett Amy, Howe Meghan, Karchemskiy Asya, Reiss Allan, Chang Kiki
Pediatric Bipolar Disorders Program, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA.
J Child Adolesc Psychopharmacol. 2011 Apr;21(2):149-55. doi: 10.1089/cap.2010.0094. Epub 2011 Apr 12.
The subgenual cingulate (SGC) cortex has been implicated in the pathophysiology of mood disorders. We sought to study morphometric characteristics of the SGC in pediatric subjects with familial bipolar disorder (BD) compared with healthy controls.
Twenty children and adolescents with BD (mean age = 14.6 years, 4 females) and 20 healthy age-, gender-, and intelligence quotient-matched controls underwent high-resolution anatomical magnetic resonance imaging. Patients were primarily euthymic and most were taking medications. SGC cortex volumes were determined by manual tracings from a reliable rater, blinded to diagnosis. Analyses of covariance were performed with total cerebral gray matter and age as covariates.
No differences were found in SGC volumes between BD subjects and healthy controls. Further analysis revealed that BD subjects with past mood stabilizer exposure had significantly increased SGC volumes compared with BD subjects without mood stabilizer exposure, and compared with controls. The increase was driven by larger bilateral posterior SGC volumes.
Youth with familial BD do not appear to have abnormalities in SGC volume. Mood stabilizer exposure, however, may be correlated with increases in SGC volume.
膝下扣带回（SGC）皮质与情绪障碍的病理生理学有关。我们试图研究家族性双相情感障碍（BD）患儿与健康对照者相比，SGC的形态学特征。
20名患有BD的儿童和青少年（平均年龄 = 14.6岁，4名女性）以及20名年龄、性别和智商匹配的健康对照者接受了高分辨率解剖磁共振成像检查。患者主要处于心境正常状态，且大多数正在服药。SGC皮质体积由一名对诊断不知情的可靠评估者通过手动描绘来确定。以全脑灰质和年龄作为协变量进行协方差分析。
BD患者和健康对照者的SGC体积没有差异。进一步分析显示，与未接触心境稳定剂的BD患者以及对照组相比，既往接触过心境稳定剂的BD患者的SGC体积显著增加。这种增加是由双侧SGC后部体积增大所致。
患有家族性BD的青少年似乎没有SGC体积异常。然而，接触心境稳定剂可能与SGC体积增加有关。
