Hadi Mohammad F, Sander Edward A, Barocas Victor H
Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
J Biomech Eng. 2012 Sep;134(9):091005. doi: 10.1115/1.4007097.
Excessive tissue-level forces communicated to the microstructure and extracellular matrix of soft tissues can lead to damage and failure through poorly understood physical processes that are multiscale in nature. In this work, we propose a multiscale mechanical model for the failure of collagenous soft tissues that incorporates spatial heterogeneity in the microstructure and links the failure of discrete collagen fibers to the material response of the tissue. The model, which is based on experimental failure data derived from different collagen gel geometries, was able to predict the mechanical response and failure of type I collagen gels, and it demonstrated that a fiber-based rule (at the micrometer scale) for discrete failure can strongly shape the macroscale failure response of the gel (at the millimeter scale). The model may be a useful tool in predicting the macroscale failure conditions for soft tissues and engineered tissue analogs. In addition, the multiscale model provides a framework for the study of failure in complex fiber-based mechanical systems in general.
传递到软组织微观结构和细胞外基质的过大组织水平力，可通过本质上多尺度且理解不足的物理过程导致损伤和失效。在这项工作中，我们提出了一种用于胶原软组织失效的多尺度力学模型，该模型纳入了微观结构中的空间异质性，并将离散胶原纤维的失效与组织的材料响应联系起来。该模型基于从不同胶原凝胶几何形状获得的实验失效数据，能够预测I型胶原凝胶的力学响应和失效，并且表明用于离散失效的基于纤维的规则（在微米尺度）可强烈塑造凝胶的宏观尺度失效响应（在毫米尺度）。该模型可能是预测软组织和工程组织类似物宏观尺度失效条件的有用工具。此外，该多尺度模型总体上为研究基于纤维的复杂力学系统中的失效提供了一个框架。
