Zhang Zeng-Li, Sun Jing, Dong Jia-Yi, Tian Hai-Lin, Xue Lian, Qin Li-Qiang, Tong Jian
Department of Health Toxicology, School of Public Health of Soochow University, Suzhou, China.
Asian Pac J Cancer Prev. 2012;13(6):2459-65. doi: 10.7314/apjcp.2012.13.6.2459.
Numbers of epidemiological studies assessing residential radon exposure and risk of lung cancer have yielded inconsistent results.
We therefore performed a meta-analysis of relevant published case- control studies searched in the PubMed database through July 2011 to examine the association. The combined odds ratio (OR) were calculated using fixed- or random-effects models. Subgroup and dose-response analyses were also performed.
We identified 22 case-control studies of residential radon and lung cancer risk involving 13,380 cases and 21,102 controls. The combined OR of lung cancer for the highest with the lowest exposure was 1.29 (95% CI 1.10-1.51). Dose-response analysis showed that every 100 Bq/m3 increment in residential radon exposure was associated with a significant 7% increase in lung cancer risk. Subgroup analysis displayed a more pronounced association in the studies conducted in Europe. Studies restricted to female or non-smokers demonstrated weakened associations between exposure and lung cancer.
This meta- analysis provides new evidence supporting the conclusion that residential exposure to radon can significantly increase the risk of lung cancer in a dose-response manner.
多项评估住宅氡暴露与肺癌风险的流行病学研究结果并不一致。
因此，我们对截至2011年7月在PubMed数据库中检索到的相关已发表病例对照研究进行了荟萃分析，以检验两者之间的关联。采用固定效应或随机效应模型计算合并比值比（OR）。还进行了亚组分析和剂量反应分析。
我们确定了22项关于住宅氡与肺癌风险的病例对照研究，涉及13380例病例和21102例对照。最高暴露组与最低暴露组相比，肺癌的合并OR为1.29（95%CI 1.10 - 1.51）。剂量反应分析表明，住宅氡暴露每增加100 Bq/m³，肺癌风险显著增加7%。亚组分析显示，在欧洲进行的研究中这种关联更为明显。仅限于女性或非吸烟者的研究表明，暴露与肺癌之间的关联减弱。
这项荟萃分析提供了新的证据，支持住宅氡暴露可通过剂量反应方式显著增加肺癌风险这一结论。
