Li Fang, Zhong Mei-Zuo, Li Jian-Huang, Liu Wei, Li Bin
Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Asian Pac J Cancer Prev. 2012;13(6):2593-6. doi: 10.7314/apjcp.2012.13.6.2593.
A case-control study of 300 gastric cancer patients and 300 controls was conducted to investigate whether the polymorphisms rs2294008 in PSCA and rs2070803 in MUC1 might be associated with risk of gastric cancer in a Chinese population.
Single nucleotide polymorphisms (SNPs) were genotyped using the Sequenom MassARRAY platform.
The data showed that the rs2294008 TT genotype increased gastric cancer risk to an adjusted odds ratio (OR) of 2.26 (95%CI 1.25-4.07), TC to 1.72 (95%CI 1.23-2.42) and TC/TT to 1.81 (95% CI 1.31-2.50), while the rs2070803 GA genotype was associated with a decrease in risk to an adjusted OR of 0.42 (95% CI 0.28-0.62) and rs2070803 GA / AA to 0.46 (95% CI 0.32-0.67). Further stratification analysis revealed that rs2294008 in PSCA consistently increased risk of both intestinal and diffuse-type gastric cancers. The effect of rs2070803 in MUC1 was noteworthily also consistent with both subtypes.
Our study suggested rs2294008 in the PSCA gene to be associated with increased risk of gastric cancer and rs2070803 in MUC1 to play a protective role in a Chinese population.
开展一项针对300例胃癌患者和300例对照的病例对照研究，以调查PSCA基因中的rs2294008多态性和MUC1基因中的rs2070803多态性是否可能与中国人群的胃癌风险相关。
使用Sequenom MassARRAY平台对单核苷酸多态性（SNP）进行基因分型。
数据显示，rs2294008的TT基因型使胃癌风险增加，调整后的优势比（OR）为2.26（95%可信区间1.25 - 4.07），TC基因型为1.72（95%可信区间1.23 - 2.42），TC/TT基因型为1.81（95%可信区间1.31 - 2.50），而rs2070803的GA基因型与风险降低相关，调整后的OR为0.42（95%可信区间0.28 - 0.62），rs2070803的GA/AA基因型为0.46（95%可信区间0.32 - 0.67）。进一步的分层分析显示，PSCA基因中的rs2294008持续增加肠型和弥漫型胃癌的风险。MUC1基因中rs2070803的作用同样值得注意，在两种亚型中均一致。
我们的研究表明，PSCA基因中的rs2294008与胃癌风险增加相关，而MUC1基因中的rs2070803在中国人群中起保护作用。
