Sreelatha S, Dinesh E, Uma C
Department of Biosciences, SRC Campus, SASTRA University, Tamilnadu, India.
Asian Pac J Cancer Prev. 2012;13(6):2775-80. doi: 10.7314/apjcp.2012.13.6.2775.
In recent years there has been a substantial increase in the use of functional foods for disease control. Fruits and vegetables produce phytochemicals such as flavonoids and antioxidants which can lower oxidative stress and reduce the risk of chronic ailments like cancer. The aim of the present study was to investigate the antioxidant capacity and the possible protective effects of Amaranthus paniculatus leaves on the antioxidant defense system in Ehrlich's ascites carcinoma (EAC) -treated mice. Oral administration of the leaf extract at different doses caused a significant decrease in tumor volume, viable cell count and tumor weight and elevated the life span of EAC bearing mice. It also showed an improved antioxidant potential as evidenced by a significant increase in the cellular antioxidant defense system such as catalase, superoxide dismutase and reduced glutathione and also significantly reduced the levels of TBARS. The levels of RBC, hemoglobin and lymphocyte count were altered in EAC bearing mice and were reverted back to near normal levels after the treatment with the leaf extracts. Their adequate content of total phenolics and flavonoids, DPPH scavenging activity which further suggests that the extracts exert a significant protection against oxidative stress conditions.
近年来，用于疾病控制的功能性食品的使用量大幅增加。水果和蔬菜会产生类黄酮和抗氧化剂等植物化学物质，这些物质可以降低氧化应激，降低患癌症等慢性疾病的风险。本研究的目的是调查尾穗苋叶的抗氧化能力以及对艾氏腹水癌（EAC）处理的小鼠抗氧化防御系统的可能保护作用。以不同剂量口服叶提取物可使肿瘤体积、活细胞计数和肿瘤重量显著降低，并延长荷EAC小鼠的寿命。它还显示出抗氧化潜力的提高，这表现为细胞抗氧化防御系统如过氧化氢酶、超氧化物歧化酶和还原型谷胱甘肽显著增加，同时丙二醛水平也显著降低。荷EAC小鼠的红细胞、血红蛋白和淋巴细胞计数水平发生了变化，在用叶提取物治疗后恢复到接近正常水平。它们总酚和类黄酮的含量充足，具有DPPH清除活性，这进一步表明提取物对氧化应激条件具有显著的保护作用。
