Department of Urology, Clinical Centre, University of Sarajevo, Bolnicka, Sarajevo, Bosnia and Herzegovina.
Bosn J Basic Med Sci. 2012 Aug;12(3):144-50. doi: 10.17305/bjbms.2012.2459.
The objective of our study was to evaluate bladder outlet obstruction number (BOON) in order to predict infravesical obstruction in patients with benign prostatic enlargement (BPE). Two hundred patients with proven BPE from daily urological practice at the Urology Department of the Sarajevo University Clinical Centre were covered by a prospective study in period 2009-2011. All patients completed International Prostatic Symptom Score, their mean voided volume urine was determined from frequency-volume chart and their prostate volume was determined by transabdominal ultrasound. Subsequently, the patients had free uroflowmetry and they underwent complete urodynamic studies. BOON was calculated using the formula: prostate volume (cc)-3 x Qmax (ml/s)-0.2 x mean voided volume (ml). A satisfactory area under the curve (AUC) was obtained for the prediction of obstruction according to bladder outlet obstruction index, Schaefer obstruction class nomogram and group specific urethral resistance factor , with AUC of 0.83 (p<0.001). Following the comparison of different cut-off values of BOON according to the obstruction, the BOON >-20 has been found to be the most accurate obstruction indicator (sensitivity 76.5% and specificity 68.2%), with posttest probability of 77%. The BOON may be used in daily urological practice as a valid, non-invasive indicator of infravesical obstruction in patients with BPE, with a possibility of correct classification of obstruction in approximately 75% of the cases. Transabdominal ultrasound has shown to be applicable to the BOON formula in determining prostate volume.
我们研究的目的是评估膀胱出口梗阻指数（BOON），以便预测良性前列腺增生（BPE）患者的下尿路梗阻。在 2009 年至 2011 年期间，萨拉热窝大学临床中心泌尿科的日常泌尿科实践中，有 200 名经证实患有 BPE 的患者参与了一项前瞻性研究。所有患者均完成了国际前列腺症状评分（IPSS），从频率-体积图表中确定其平均排尿量，并通过经腹超声确定其前列腺体积。随后，患者进行了自由尿流率检查，并进行了完整的尿动力学研究。BOON 通过以下公式计算：前列腺体积（cc）-3 x Qmax（ml/s）-0.2 x 平均排尿量（ml）。根据膀胱出口梗阻指数、Schaeffer 梗阻分级图和特定组尿道阻力因子，BOON 对梗阻的预测得到了令人满意的曲线下面积（AUC），AUC 为 0.83（p<0.001）。根据梗阻比较 BOON 的不同截断值后，发现 BOON>-20 是最准确的梗阻指标（灵敏度 76.5%，特异性 68.2%），后验概率为 77%。BOON 可在日常泌尿科实践中用作 BPE 患者下尿路梗阻的有效、非侵入性指标，大约 75%的病例可以正确分类梗阻。经腹超声在确定前列腺体积方面适用于 BOON 公式。
