Personal Chemical Exposure Program, Environmental Toxicology Graduate Program Department of Entomology, University of California, Riverside, California, USA.
J Environ Sci Health B. 2012;47(10):913-24. doi: 10.1080/03601234.2012.706548.
Use of fipronil {5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile CAS 120068-37-3} topical pet products on dogs and cats introduces low level residues into residences. Distribution and fate studies of fipronil on pets and in residences were performed to evaluate potential determinants of human exposure. Fipronil, desulfinyl fipronil, fipronil sulfone and fipronil sulfide were measured on hair clippings and brushed hair. The derivatives usually represented <10% of fipronil applied. Cotton gloves worn over impervious nitrile gloves, cotton cloths placed indoors in locations frequented by pets, and cotton socks worn by residents as direct dosimeters collected fipronil and its derivatives listed above in low amounts during 4-week study periods. Subsequent acid hydrolysis urine biomonitoring did not reveal significant excretion of biomarkers at ppb levels. The human exposure potential of fipronil is low relative to levels of health concern.
在狗和猫身上使用氟虫腈{5-氨基-1-[2,6-二氯-4-(三氟甲基)苯基]-4-三氟甲基亚磺酰基]-1H-吡唑-3-甲腈 CAS 120068-37-3}局部宠物产品会将低水平的残留物引入住宅。对宠物和住宅中氟虫腈的分布和归宿研究进行了评估，以评估人类接触的潜在决定因素。在剪下的毛发和刷过的毛发上检测到了氟虫腈、去磺氟虫腈、氟虫腈砜和氟虫腈硫醚。这些衍生物通常代表施用量的<10%。在为期 4 周的研究期间，戴在不透水丁腈手套上的棉手套、放在宠物常出没室内的棉织物以及居民直接穿的棉袜作为直接剂量计，收集了上述氟虫腈及其衍生物的低量。随后的酸水解尿液生物监测未显示出显著的 ppb 水平生物标志物排泄。与关注的健康水平相比，氟虫腈的人类暴露潜力较低。
