Dept. of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA.
Vet Parasitol. 2011 Dec 15;182(2-4):281-6. doi: 10.1016/j.vetpar.2011.05.054. Epub 2011 Jun 12.
Thirteen cats and 7 dogs living in 14 homes were treated topically with either a dinotefuran (22%, w/w)/pyriproxyfen (3.00%, w/w) (DP) or dinotefuran (4.95%, w/w)/pyriproxyfen (0.44%, w/w)/permethrin (36.08%, w/w) (DPP) topical spot-on, respectively. Twenty cats and 7 dogs living in 16 homes were treated topically with either a fipronil (9.8%, w/w)/(S)-methoprene (11.8%, w/w) or fipronil (9.8%, w/w)/(S)-methoprene (8.8%, w/w) topical spot-on (FM), respectively. All products were applied according to label directions by study investigators on day 0 and again between days 28 and 30. Flea populations on pets were assessed using visual area counts and premise flea infestations were assessed using intermittent-light flea traps on days 0, 7, 14, 21, 28-30, 40-45, and 54-60. A single application of the DP-DPP and FM formations reduced flea populations by 87.35% and 88.44%, respectively within 7 days. Following two monthly applications of either the DP-DPP or FM formulations, pet flea burdens were reduced by 95.24% and 95.47%, respectively. Flea numbers in the indoor-premises were also markedly reduced by days 54-60, with 98.05% and 96.15% reductions in intermittent-light flea trap counts in the DP-DPP or FM treatment groups, respectively.
十三只猫和七只狗生活在 14 个家庭中，分别接受了二氯苯醚菊酯（22%，w/w）/吡丙醚（3.00%，w/w）（DP）或二氯苯醚菊酯（4.95%，w/w）/吡丙醚（0.44%，w/w）/氯菊酯（36.08%，w/w）（DPP）的局部点涂治疗。二十只猫和七只狗生活在 16 个家庭中，分别接受了氟虫腈（9.8%，w/w）/（S）-烯虫酯（11.8%，w/w）或氟虫腈（9.8%，w/w）/（S）-烯虫酯（8.8%，w/w）的局部点涂治疗（FM），治疗均由研究人员根据标签说明在第 0 天和第 28-30 天进行。在第 0、7、14、21、28-30、40-45 和 54-60 天，通过目测面积计数评估宠物身上的跳蚤数量，并通过间歇性灯光跳蚤陷阱评估室内环境中的跳蚤侵扰情况。DP-DPP 和 FM 制剂单次使用后，7 天内分别使跳蚤种群减少了 87.35%和 88.44%。在每月使用 DP-DPP 或 FM 制剂两次后，宠物身上的跳蚤负担分别减少了 95.24%和 95.47%。到第 54-60 天，室内环境中的跳蚤数量也明显减少，DP-DPP 或 FM 治疗组间歇性灯光跳蚤陷阱计数分别减少了 98.05%和 96.15%。
