Dryden M W, Denenberg T M, Bunch S
Department of Diagnostic Medicine/Pathobiology, 1800 Denison Avenue, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
Vet Parasitol. 2000 Nov 1;93(1):69-75. doi: 10.1016/s0304-4017(00)00318-6.
Thirty-four flea-infested dogs and cats residing in 20 homes in Tampa, FL were randomly placed into 1 of 2 treatment groups during the summer of 1997. Pets were treated topically with either 10.0%w/v imidacloprid or 10%w/v fipronil spot-on on day 0, then once for every 28-30 days for 90 days. Flea populations were assessed in the environment using an intermittent-light trap, while pet flea burdens were assessed using visual area counts. A single application of imidacloprid was 95.3 and 97.4% effective in reducing flea populations on pets at 7 and 28 days, respectively. A single application of fipronil was 97.5 and 97.0% effective in reducing flea populations on pets at the same time points. Following 3 monthly applications of either imidacloprid or fipronil, flea burdens on pets were reduced by 99.5 and 96.5%, respectively. In addition, flea numbers in the in-home environment were reduced by 99. 0 and 98.6% in homes, where pets were treated with imidacloprid or fipronil, respectively.
1997年夏天，佛罗里达州坦帕市20户家庭中的34只感染跳蚤的狗和猫被随机分为两个治疗组中的一组。在第0天，宠物分别局部使用10.0%（w/v）吡虫啉或10%（w/v）氟虫腈滴剂进行治疗，然后每28 - 30天进行一次治疗，持续90天。使用间歇式诱虫灯评估环境中的跳蚤数量，同时通过目视计数评估宠物身上的跳蚤负担。单次使用吡虫啉在第7天和第28天分别对减少宠物身上的跳蚤数量有95.3%和97.4%的效果。单次使用氟虫腈在相同时间点对减少宠物身上的跳蚤数量有97.5%和97.0%的效果。在分别每月使用吡虫啉或氟虫腈三次后，宠物身上的跳蚤负担分别减少了99.5%和96.5%。此外，在使用吡虫啉或氟虫腈治疗宠物的家庭中，家庭环境中的跳蚤数量分别减少了99.0%和98.6%。
