急性非淋巴细胞白血病中的新型易位。两例涉及21号染色体q22带。
Novel translocations in acute nonlymphocytic leukemia. Two cases involving chromosome 21, band q22.
作者信息
Peters G B, Dale B M, Sage R E, Ford J H
机构信息
Department of Genetics, Queen Elizabeth Hospital, Woodville, South Australia.
出版信息
Cancer Genet Cytogenet. 1990 Jan;44(1):99-105. doi: 10.1016/0165-4608(90)90202-l.
We present two cases in which translocations involving 21q22 were found at presentation in acute nonlymphocytic leukemia (ANLL). The first of these translocations, t(3;21)(q26-q27;q22), is previously unknown in ANLL, but appears indistinguishable from that reportedly associated with Philadelphia-positive chronic myelogenous leukemia. The second case involves t(15;21)(q21-q22;q22), a translocation previously undescribed in ANLL. Both of these exchanges involve 21q22 plus another chromosome region associated with leukemogenesis. We attempted to interrelate these cytogenetic data with the oncogenic significance of 21q22.
我们报告了两例急性非淋巴细胞白血病（ANLL）患者，在初诊时发现了涉及21q22的易位。其中第一个易位，t(3;21)(q26 - q27;q22)，在ANLL中此前未知，但似乎与据报道与费城染色体阳性慢性粒细胞白血病相关的易位无法区分。第二例涉及t(15;21)(q21 - q22;q22)，这是一种此前在ANLL中未描述过的易位。这两种交换都涉及21q22以及另一个与白血病发生相关的染色体区域。我们试图将这些细胞遗传学数据与21q22的致癌意义联系起来。
Zotero 插件