Korver A M H, van Zanten G A, Meuwese-Jongejeugd A, van Straaten H L M, Oudesluys-Murphy A M
Willem-Alexander Children's Hospital, Sub Department of Social Pediatrics, Leiden University Medical Center, The Netherlands.
Int J Pediatr Otorhinolaryngol. 2012 Dec;76(12):1708-11. doi: 10.1016/j.ijporl.2012.08.009. Epub 2012 Aug 31.
Collect all available published evidence on the prevalence of auditory neuropathy in the well baby population and calculate the contribution of this to the false negative rate of oto-acoustic emission based newborn hearing screening programs.
PubMed and EMBASE were searched for relevant articles published between 1996 and 2010. Medical Subject Headings terms included 'Auditory disease', 'Prevalence' and 'Child' and their relevant synonyms. Included were original studies, which focused on well babies and reported the prevalence of auditory neuropathy.
Of 519 citations 4 articles met the inclusion criteria. The population based prevalence of auditory neuropathy in children in population hearing screening was found to vary between 0.006% (SD 0.006) and 0.03% (SD 0.02). The false negative rate, caused by missed children with auditory neuropathy, is between 4 and 17%.
The available information on the prevalence of auditory neuropathy in the well baby population is poor. However, if oto-acoustic emission screening is used in the first stage of a neonatal hearing screening program, children with auditory neuropathy are missed. The cost-effectiveness of population-based screening using auditory brainstem response should be studied.
收集所有已发表的关于健康婴儿群体中听神经病患病率的可用证据，并计算其对基于耳声发射的新生儿听力筛查项目假阴性率的影响。
检索1996年至2010年间发表在PubMed和EMBASE上的相关文章。医学主题词包括“听觉疾病”、“患病率”和“儿童”及其相关同义词。纳入的是针对健康婴儿并报告听神经病患病率的原始研究。
在519条引用文献中，有4篇文章符合纳入标准。在人群听力筛查中，儿童听神经病的人群患病率在0.006%（标准差0.006）至0.03%（标准差0.02）之间。因漏诊听神经病患儿导致的假阴性率在4%至17%之间。
关于健康婴儿群体中听神经病患病率的现有信息不足。然而，如果在新生儿听力筛查项目的第一阶段使用耳声发射筛查，听神经病患儿会被漏诊。应研究使用听性脑干反应进行人群筛查的成本效益。
