合成代谢雄激素对乳糜微粒代谢的影响。

Effects of anabolic androgenic steroids on chylomicron metabolism.

机构信息

Heart Institute (InCor) of Medical School Hospital, University of São Paulo, São Paulo, Brazil.

出版信息

Steroids. 2012 Nov;77(13):1321-6. doi: 10.1016/j.steroids.2012.08.004. Epub 2012 Aug 23.

DOI:10.1016/j.steroids.2012.08.004

PMID:22939845

Abstract

OBJECTIVE

To evaluate the effects of anabolic androgenic steroids (AAS) on chylomicron metabolism.

METHODS

An artificial lipid emulsion labeled with radioactive cholesteryl ester (CE) and triglycerides (TG) mimicking chylomicrons was intravenously injected into individuals who regularly weight trained and made regular use of AAS (WT+AAS group), normolipidemic sedentary individuals (SDT group) and individuals who also regularly weight trained but did not use AAS (WT group). Fractional clearance rates (FCR) were determined by compartmental analysis for emulsion plasma decay curves.

RESULTS

FCR-CE for the WT+AAS group was reduced (0.0073 ± 0.0079 min(-1), 0.0155 ± 0.0100 min(-1), 0.0149 ± 0.0160 min(-1), respectively; p<0.05), FCR-TG was similar for both the WT and SDT groups. HDL-C plasma concentrations were lower in the WT+AAS group when compared to the WT and SDT groups (22 ± 13; 41 ± 7; 38 ± 13 mg/dL, respectively; p<0.001). Hepatic triglyceride lipase activity was greater in the WT+AAS group when compared to the WT and SDT groups (7243 ± 1822; 3898 ± 1232; 2058 ± 749, respectively; p<0.001). However, no difference was observed for lipoprotein lipase activity.

CONCLUSIONS

Data strongly suggest that AAS may reduce the removal from the plasma of chylomicron remnants, which are known atherogenic factors.

摘要

目的

评估合成代谢雄激素类固醇（AAS）对乳糜微粒代谢的影响。

方法

通过静脉注射一种人工脂质乳液，该乳液标记有放射性胆甾醇酯（CE）和甘油三酯（TG），模拟乳糜微粒，将其注射给经常进行重量训练且定期使用 AAS 的个体（WT+AAS 组）、血脂正常的久坐个体（SDT 组）和经常进行重量训练但不使用 AAS 的个体（WT 组）。通过对乳液血浆衰减曲线的房室分析来确定分数清除率（FCR）。

结果

WT+AAS 组的 FCR-CE 降低（分别为 0.0073 ± 0.0079、0.0155 ± 0.0100、0.0149 ± 0.0160 min(-1)，p<0.05），WT 组和 SDT 组的 FCR-TG 相似。与 WT 组和 SDT 组相比，WT+AAS 组的 HDL-C 血浆浓度更低（分别为 22 ± 13、41 ± 7、38 ± 13 mg/dL，p<0.001）。与 WT 组和 SDT 组相比，WT+AAS 组的肝甘油三酯脂肪酶活性更高（分别为 7243 ± 1822、3898 ± 1232、2058 ± 749，p<0.001）。然而，脂蛋白脂肪酶活性没有差异。